4-Amino-3-(2-thienyl)butanoic acid

Base Information

Chemical Name:4-Amino-3-(2-thienyl)butanoic acid
CAS No.:98593-59-0
Molecular Formula:C8H11NO2S
Molecular Weight:185.24300
Hs Code.:
DSSTox Substance ID:DTXSID60928352
Nikkaji Number:J421.289D
ChEMBL ID:CHEMBL315476

Synonyms:2-BTG;4-amino-3-(2-thienyl)butanoic acid;beta-(2-thienyl)-gamma-aminobutyric acid

Suppliers and Price of 4-Amino-3-(2-thienyl)butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-Amino-3-(2-thienyl)butanoic acid

Chemical Property:

PSA：91.56000
LogP:1.96540
XLogP3:-2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:185.05104977
Heavy Atom Count:12
Complexity:163

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC(=C1)C(CC(=O)O)CN

Technology Process of 4-Amino-3-(2-thienyl)butanoic acid

There total 4 articles about 4-Amino-3-(2-thienyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133933-46-7
ethyl 4-nitro-3-(thiophen-2-yl)butanoate

: 98593-59-0,133933-76-3
4-amino-3-(thien-2-yl)butanoic acid

Guidance literature:: With sodium hydroxide; ethanol; hydrogen; nickel; Yield given. Multistep reaction; 1.) EtOH, 1 atm, RT, 2.) reflux, 1 h;
DOI:10.1021/jm00112a033

Reference yield:

: 13979-15-2,70326-81-7
ethyl (E)-3-(thiophen-2-yl)acrylate

: 98593-59-0,133933-76-3
4-amino-3-(thien-2-yl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / Triton B / 18 h / 85 °C

2: 1.) H₂, 2.) 10 N NaOH, aq. EtOH / 1.) Raney Ni / 1.) EtOH, 1 atm, RT, 2.) reflux, 1 h

With sodium hydroxide; ethanol; hydrogen; N-benzyl-trimethylammonium hydroxide; nickel;
DOI:10.1021/jm00112a033