Technology Process of 1H-Pyrrole-2-carboxylic acid,
4,4'-[(2,5-dimethoxy-1,4-phenylene)di-5-hexene-6,1-diyl]bis[3-methyl-,
diethyl ester
There total 15 articles about 1H-Pyrrole-2-carboxylic acid,
4,4'-[(2,5-dimethoxy-1,4-phenylene)di-5-hexene-6,1-diyl]bis[3-methyl-,
diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) DMSO/(COCl)2, 2.)Et3N / 1.) methylene chloride, -78 deg C, 15 min, 2.) methylene chloride, from -78 deg C to RT
2: K2CO3 / dioxane / Heating
With
oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
1,4-dioxane;
DOI:10.1021/jo00233a011
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaHCO3, 2.) KI/I2 / 1.) water, EtCl2, reflux, 2.) water, EtCl2, reflux, 30 min
2: 87.5 percent / KI, conc. HCl / ethanol / 0.25 h / Heating
3: 96.6 percent / toluene / 25 h / Heating
4: K2CO3 / dioxane / Heating
With
hydrogenchloride; iodine; sodium hydrogencarbonate; potassium carbonate; potassium iodide;
In
1,4-dioxane; ethanol; toluene;
DOI:10.1021/jo00233a011
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 87.5 percent / KI, conc. HCl / ethanol / 0.25 h / Heating
2: 96.6 percent / toluene / 25 h / Heating
3: K2CO3 / dioxane / Heating
With
hydrogenchloride; potassium carbonate; potassium iodide;
In
1,4-dioxane; ethanol; toluene;
DOI:10.1021/jo00233a011
