Dilevalol

Base Information

Chemical Name:Dilevalol
CAS No.:75659-07-3
Molecular Formula:C19H24 N2 O3
Molecular Weight:328.411
Hs Code.:
European Community (EC) Number:276-693-0
UNII:P6629XE33T
DSSTox Substance ID:DTXSID2043828
Nikkaji Number:J23.747G
Wikidata:Q27166331
NCI Thesaurus Code:C65390
ChEMBL ID:CHEMBL27193
Mol file:75659-07-3.mol

Synonyms:AH 5158;AH-5158;AH5158;Albetol;Apo Labetalol;Apo-Labetalol;ApoLabetalol;Dilevalol;Hydrochloride, Labetalol;Labetalol;Labetalol Hydrochloride;Labetalol, (R,R)-Isomer;Labetolol;Normodyne;Presolol;R,R Labetalol;R,R-Labetalol;SCH 19927;SCH-19927;SCH19927;Trandate

Suppliers and Price of Dilevalol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-4-phenylbutan-2-yl)amino)ethyl)benzamide 95+%
1g
$ 1583.00

Biosynth Carbosynth
Dilevalol
50 mg
$ 507.50

Biosynth Carbosynth
Dilevalol
10 mg
$ 145.00

American Custom Chemicals Corporation
2-HYDROXY-5-((R)-1-HYDROXY-2-(((R)-4-PHENYLBUTAN-2-YL)AMINO)ETHYL)BENZAMIDE 95.00%
1G
$ 3104.85

American Custom Chemicals Corporation
2-HYDROXY-5-((R)-1-HYDROXY-2-(((R)-4-PHENYLBUTAN-2-YL)AMINO)ETHYL)BENZAMIDE 95.00%
5MG
$ 498.88

Total 16 raw suppliers

Chemical Property of Dilevalol

Chemical Property:

Vapor Pressure:4.75E-13mmHg at 25°C
Boiling Point:552.7°C at 760 mmHg
PKA:8.21±0.31(Predicted)
Flash Point:288.1°C
PSA：95.58000
Density:1.2g/cm³
LogP:3.22660
XLogP3:3.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:328.17869263
Heavy Atom Count:24
Complexity:385

Purity/Quality:

98% Min ^*data from raw suppliers

2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-4-phenylbutan-2-yl)amino)ethyl)benzamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O
Isomeric SMILES:C[C@H](CCC1=CC=CC=C1)NC[C@@H](C2=CC(=C(C=C2)O)C(=O)N)O
Description Dilevalol is a "dual-mechanism" antihypertensive reportedly suitable for a wide range of patients. Its partial beta2-agonist action is expected to induce vasodilation, whereas its beta1-antagonist component may protect against stress-induced hemodynamic charges without altering the cardiac output. Dilevalol is the R,R-isomer of labetalol.
Uses Specific competitive antagonist at both α-and β-adrenergic receptor sites. Antihypertensive. (R,R)-Labetalol is a specific competitive antagonist at both α-and β-adrenergic receptor sites. (R,R)-Labetalol is used as an antihypertensive.

Technology Process of Dilevalol

There total 19 articles about Dilevalol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

: 75615-55-3
*,R^*)>-5-<1-hydroxy-2-ethyl>-2-(phenylmethoxy)benzamide

: 75659-07-3
(R,R)-labetalol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00348a013