Thiazolo[4,5-b]pyridine-2(3H)-thione

Base Information

• Chemical Name: Thiazolo[4,5-b]pyridine-2(3H)-thione
• CAS No.: 99158-61-9
• Molecular Formula: C6H4N2S2
• Molecular Weight: 168.23900
• Hs Code.: 2934999090
• Mol file: 99158-61-9.mol

Synonyms:thiazolo[4,5-b]pyridine-2(3H)-thione;[1,3]thiazolo[4,5-b]pyridine-2-thiol;2-Mercaptothiazolo[4,5-b]pyridine;THIAZOLO[4,5-B]PYRIDINE-2-THIOL;

Chemical Property of Thiazolo[4,5-b]pyridine-2(3H)-thione

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >300 °C
• Boiling Point: 317.2±25.0 °C(Predicted)
• PKA: -1.23±0.20(Predicted)
• PSA: 92.82000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 1.98000
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Thiazolo[4,5-B]pyridine-2-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiazolo[4,5-b]pyridine-2(3H)-thione

There total 5 articles about Thiazolo[4,5-b]pyridine-2(3H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-amino-3-chloropyridine (39620-04-7) + potassium ethyl xanthogenate (140-89-6) → thiazolo[4,5-b]pyridine-2(3H)-thione (99158-61-9)

Guidance literature:

2-amino-3-chloropyridine; potassium ethyl xanthogenate; In 1-methyl-pyrrolidin-2-one; at 150 ℃;

With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield: 88.0%

→ 2-mercaptothiazolo[4,5-b]pyridine (99158-61-9)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 150 ℃;

Reference yield: 75.0%

3-(N,N-diisopropylthiocarbamato)-2-(pivaloylamino)pyridine → thiazolo[4,5-b]pyridine-2(3H)-thione (99158-61-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 4h; Heating;

DOI:10.1016/j.ejmech.2004.09.010

upstream raw materials:

2-Amino-3-bromopyridine

potassium ethyl xanthogenate

2-amino-3-chloropyridine

Downstream raw materials:

2-chlorothiazolo<4,5-b>pyridine

2-(methylthio)[1,3]thiazolo[4,5-b]pyridine

(6R,7R)-7-{2-[(Z)-(S)-1-Benzhydryloxycarbonyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(thiazolo[4,5-b]pyridin-2-ylsulfanylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

(6R,7R)-7-{2-[(Z)-Benzhydryloxycarbonylmethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(thiazolo[4,5-b]pyridin-2-ylsulfanylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Refernces

• 1、 -. "ISOINDOLINES AS HDAC INHIBITORS". Paragraph 00204. . Retrieved 2019/11/12.
• 2、 -. "BICYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF". Page/Page column 49-50. . Retrieved 2010/08/05.