6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

Base Information

Chemical Name:6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol
CAS No.:99199-62-9
Molecular Formula:C10H11FO2
Molecular Weight:182.195
Hs Code.:
European Community (EC) Number:829-955-9
DSSTox Substance ID:DTXSID80472645
Mol file:99199-62-9.mol

Synonyms:99199-62-9;6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol;rac 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol;(6-fluorochroman-2-yl)methanol;(6-fluoro-3,4-dihydro-2H-chromen-2-yl)methanol;starbld0001380;SCHEMBL935303;DTXSID80472645;HAIDNNYCHKHYHX-UHFFFAOYSA-N;AKOS037505729;FT-0668632;EN300-6495182;(6-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-YL)METHANOL

Suppliers and Price of 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol
10g
$ 5819.00

Total 6 raw suppliers

Chemical Property of 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

Chemical Property:

PSA：29.46000
LogP:1.51160
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate, Methanol
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:182.07430775
Heavy Atom Count:13
Complexity:174

Purity/Quality:

95% ^*data from raw suppliers

6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C=CC(=C2)F)OC1CO

Technology Process of 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

There total 5 articles about 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 99199-60-7,129050-20-0
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

: 99199-62-9
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

Guidance literature:: 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; With sodium tetrahydroborate; sulfuric acid; In tetrahydrofuran; diethyl ether; at 0 - 35 ℃; for 0.75h;

With sodium hydroxide; In water; pH=7; Product distribution / selectivity;

Reference yield:

: 874649-82-8
(-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate

: 409346-73-2
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde

: 99199-62-9
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; isopropyl alcohol; toluene; at -78 - -73 ℃; Concentration; Solvent; Inert atmosphere;

Reference yield:

: 99199-60-7,129050-20-0
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

: 409346-73-2
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde

: 99199-62-9
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 25 - 30 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene; isopropyl alcohol / -78 - -73 °C / Inert atmosphere

With sulfuric acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; isopropyl alcohol; toluene;