Carbamic acid, [(1S,2E)-3-(methylsulfonyl)-1-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2E)-3-(methylsulfonyl)-1-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester
CAS No.:99281-93-3
Molecular Formula:C16H23NO4S
Molecular Weight:325.429
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [(1S,2E)-3-(methylsulfonyl)-1-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1S,2E)-3-(methylsulfonyl)-1-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester

There total 13 articles about Carbamic acid, [(1S,2E)-3-(methylsulfonyl)-1-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 99281-93-3
(3S,E)-3-(tert-butoxycarbonylamino)-4-phenyl-1-methylsulfonyl-1-butene

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / ethyl acetate / 20 °C

2: Ph₃P; diisopropyl azodicarboxylate / CHCl₃ / Heating

3: methanol / 0.5 h / Heating

4: m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

5: 4-(N,N-dimethylamino)pyridine; mesyl chloride / CH₂Cl₂ / 0 - 20 °C

With dmap; di-isopropyl azodicarboxylate; hydrogen; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; chloroform; ethyl acetate; 2: Mitsunobu cyclization;
DOI:10.1021/jo0268456

Reference yield:

: 799560-25-1
(2S,3S)-3-(tert-butoxycarbonylamino)-4-phenyl-1-methylsulfonyl-2-butanol

: 99281-93-3
(3S,E)-3-(tert-butoxycarbonylamino)-4-phenyl-1-methylsulfonyl-1-butene

Guidance literature:: With dmap; methanesulfonyl chloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo0268456

Reference yield:

: 42238-15-3,22910-59-4,49676-93-9
(2E)-4-phenylbut-2-en-1-ol

: 99281-93-3
(3S,E)-3-(tert-butoxycarbonylamino)-4-phenyl-1-methylsulfonyl-1-butene

Guidance literature:: Multi-step reaction with 7 steps

1: Ti(O-i-Pr)4; D(-)-DIPT; t-BuOOH / CH₂Cl₂ / -20 °C

2: Ti(O-i-Pr)2(N₃)2 / benzene / Heating

3: H₂ / Pd/C / ethyl acetate / 20 °C

4: Ph₃P; diisopropyl azodicarboxylate / CHCl₃ / Heating

5: methanol / 0.5 h / Heating

6: m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

7: 4-(N,N-dimethylamino)pyridine; mesyl chloride / CH₂Cl₂ / 0 - 20 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; diisopropoxytitanium diazide; di-isopropyl azodicarboxylate; hydrogen; D-(-)-diisopropyl tartrate; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; chloroform; ethyl acetate; benzene; 1: asymmetric Sharpless epoxidation / 4: Mitsunobu cyclization;
DOI:10.1021/jo0268456