Heptanoic acid, 3-methyl-, methyl ester, (R)-

Base Information

• Chemical Name: Heptanoic acid, 3-methyl-, methyl ester, (R)-
• CAS No.: 99439-80-2
• Molecular Formula: C₉H₁₈O₂
• Molecular Weight: 158.241
• Mol file: 99439-80-2.mol

Synonyms:

Chemical Property of Heptanoic acid, 3-methyl-, methyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Heptanoic acid, 3-methyl-, methyl ester, (R)-

There total 3 articles about Heptanoic acid, 3-methyl-, methyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-butyl magnesium bromide (693-03-8) + crotonic acid methyl ester (623-43-8) → (S)-(-)-methyl 3-methylheptanoate (99439-79-9) + (R)-3-methylheptanoic acid methyl ester (99439-80-2)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; (R,S)-JOSIPHOS; In diethyl ether; at -75 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1002/anie.200500317

Reference yield:

C25H35NO4S → (S)-(-)-methyl 3-methylheptanoate (99439-79-9) + (R)-3-methylheptanoic acid methyl ester (99439-80-2)

Guidance literature:

With aluminum amalgam; acetic acid; In tetrahydrofuran; water; at 23 ℃; for 1.5h; Title compound not separated from byproducts;

DOI:10.1021/jo00351a017

Reference yield:

C25H35NO4S → (S)-(-)-methyl 3-methylheptanoate (99439-79-9) + (R)-3-methylheptanoic acid methyl ester (99439-80-2)

Guidance literature:

With aluminum amalgam; acetic acid; In tetrahydrofuran; water; at 23 ℃; for 1.5h; Title compound not separated from byproducts;

DOI:10.1021/jo00351a017

upstream raw materials:

n-butyl magnesium bromide

crotonic acid methyl ester

Downstream raw materials:

(R)-(+)-3-Methyl-1-heptanol

Refernces

• 1、 Pyne, Stephen G.. "Asymmetric Conjugate Addition of Organometallic Reagents to Chiral Vinyl Sulfoximines". . p. 81 - 87. Retrieved 2007/10/02.