3-(4-Chlorobenzylidene)indolin-2-one

Base Information

Chemical Name:3-(4-Chlorobenzylidene)indolin-2-one
CAS No.:3335-90-8
Molecular Formula:C15H10ClNO
Molecular Weight:255.703
Hs Code.:
NSC Number:13587
Nikkaji Number:J1.819.666B
ChEMBL ID:CHEMBL3633198

Synonyms:3335-90-8;3-(4-chlorobenzylidene)indolin-2-one;CHEMBL3633198;NSC13587;(3Z)-3-[(4-chlorophenyl)methylidene]-1H-indol-2-one;SCHEMBL1973434;SCHEMBL1973436;CIXKMQYKNWKSNZ-LCYFTJDESA-N;(3Z)-3-[(4-chlorophenyl)methylidene]-2,3-dihydro-1H-indol-2-one;BDBM50130934;MFCD00435355;NSC-13587;AKOS016032053;3-(4-Chlorobenzylidene)indoline-2-one;NS-03879;(Z)-3-(4-chloro-benzylidene)-1,3-dihydro-indol-2-one;(3z)-3-(4-chlorobenzylidene)-1,3-dihydro-2h-indol-2-one

Suppliers and Price of 3-(4-Chlorobenzylidene)indolin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 3-(4-Chlorobenzylidene)indolin-2-one

Chemical Property:

Vapor Pressure:4.65E-09mmHg at 25°C
Boiling Point:471.4°Cat760mmHg
Flash Point:238.9°C
Density:1.34g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:255.0450916
Heavy Atom Count:18
Complexity:358

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=CC3=CC=C(C=C3)Cl)C(=O)N2
Isomeric SMILES:C1=CC=C2C(=C1)/C(=C/C3=CC=C(C=C3)Cl)/C(=O)N2

Technology Process of 3-(4-Chlorobenzylidene)indolin-2-one

There total 4 articles about 3-(4-Chlorobenzylidene)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 59-48-3
2-oxoindole

: 104-88-1
4-chlorobenzaldehyde

: 3335-90-8
3-(4-chlorobenzylidene)indolin-2-one

Guidance literature:: With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate; at 80 ℃; for 1h;
DOI:10.1515/HC.2008.14.4.263

Reference yield:

: 16327-29-0
2-indolinone

: 104-88-1
4-chlorobenzaldehyde

: 3335-90-8
3-(4-chlorobenzylidene)indolin-2-one

Guidance literature:: With piperidine; In ethanol; for 2h; Reflux; Inert atmosphere;
DOI:10.1021/ol300687s

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 3335-90-8
3-(4-chlorobenzylidene)indolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / 4 h / 140 °C

1.2: 48 h / 20 °C

2.1: piperidine / ethanol / 90 °C

With piperidine; hydrazine hydrate; In ethanol; 1.1: Wolff-Kishner reduction;
DOI:10.1248/cpb.59.1285