PDK1 inhibitor

Base Information

• Chemical Name: PDK1 inhibitor
• CAS No.: 1001409-50-2
• Molecular Formula: C28H22F2N4O4
• Molecular Weight: 516.4954864
• Mol file: 1001409-50-2.mol

Synonyms:PDK1 inhibitor;1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-

Chemical Property of PDK1 inhibitor

Chemical Property:

• Boiling Point: 724.4±60.0 °C(Predicted)
• PKA: 11.48±0.20(Predicted)
• PSA: 109.24000
• Density: 1.398
• LogP: 4.69770
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

PDK1inhibitor >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PDK1 inhibitor

There total 5 articles about PDK1 inhibitor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H24F2N4O3 + 1,1'-carbonyldiimidazole (530-62-1) → (1-(3,4-difluorobenzyl)-2-oxo-N-{1(R)-2-[(2-oxo2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide) (1001409-50-2)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 4h;

DOI:10.1016/j.bmcl.2011.03.032

Reference yield:

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (1001413-01-9) → (1-(3,4-difluorobenzyl)-2-oxo-N-{1(R)-2-[(2-oxo2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide) (1001409-50-2)

Guidance literature:

Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3: hydrogenchloride; zinc / methanol; water; isopropyl alcohol / 2 h / 20 °C

4: N,N-dimethyl-formamide / 4 h / 60 °C

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.03.032

Reference yield:

C21H18F2N2O3 (1001413-68-8) → (1-(3,4-difluorobenzyl)-2-oxo-N-{1(R)-2-[(2-oxo2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide) (1001409-50-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: hydrogenchloride; zinc / methanol; water; isopropyl alcohol / 2 h / 20 °C

3: N,N-dimethyl-formamide / 4 h / 60 °C

With hydrogenchloride; sodium hydride; zinc; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.03.032

upstream raw materials:

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

C₂₁H₁₈F₂N₂O₃

1,1'-carbonyldiimidazole

D-2-phenylglycinol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1001409-50-2 PDK1 inhibitor

Send

Send

Metric Ton KG G Pound L ML

Send

Send