5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Base Information

• Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
• CAS No.: 1048371-03-4
• Molecular Formula: C17H13NO3
• Molecular Weight: 281
• Mol file: 1048371-03-4.mol

Synonyms:5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one;UPF 1069;5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-

Chemical Property of 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property:

• PSA: 59.42000
• LogP: 3.20210
• Storage Temp.: Store at RT
• Solubility.: Soluble in DMSO (up to 40 mg/ml).

Purity/Quality:

99%, ^*data from raw suppliers

5-Phenacyloxy-2H-isoquinolin-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Description: UPF-1069 (1048371-03-4) is a selective PARP-2 inhibitor (IC50=0.3 μM and ~ 27-fold selective against PARP-1).1,2?Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3?Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4
• Uses: UPF 1069, is a Selective PARP-2 inhibitor.

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