Chemical Property of Ethyl 2-{[5-(methylsulfanyl)thiophen-2-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
Chemical Property:
- Boiling Point:535.7±50.0 °C(Predicted)
- PKA:-3.20±0.40(Predicted)
- PSA：100.15000
- Density:1.32±0.1 g/cm3(Predicted)
- LogP:3.53810
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥30mg/mL
- XLogP3:4.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:361.08063582
- Heavy Atom Count:24
- Complexity:473
- Purity/Quality:
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99%, *data from raw suppliers
SR 8278 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC
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Description
REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.
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Uses
SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.
