Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)-

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)-
CAS No.:934995-87-6
Molecular Formula:C₂₈H₂₂FN₃O₄
Molecular Weight:483.499
Hs Code.:
UNII:N48GH1UIR0
ChEMBL ID:CHEMBL1801160
Wikidata:Q27284533

Synonyms:MK-0952

Suppliers and Price of Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MK-0952 95.00%
5MG
$ 497.52

Total 2 raw suppliers

Chemical Property of Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)-

Chemical Property:

PSA：104.78000
LogP:4.84690
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:483.15943435
Heavy Atom Count:36
Complexity:936

Purity/Quality:

95% ^*data from raw suppliers

MK-0952 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1NC(=O)C2=CN(C3=C(C2=O)C=CC=N3)C4=CC=CC(=C4)C5=CC(=C(C=C5)C6CC6C(=O)O)F
Isomeric SMILES:C1CC1NC(=O)C2=CN(C3=C(C2=O)C=CC=N3)C4=CC=CC(=C4)C5=CC(=C(C=C5)[C@@H]6C[C@H]6C(=O)O)F
Recent EU Clinical Trials:A Phase IIa, Randomized, Double-Blind, Placebo-Controlled, 2-Period Crossover Study to Assess the Efficacy and Safety of MK-0952 in Patients With Alzheimer’s Disease

Technology Process of Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)-

There total 5 articles about Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 934995-86-5
C₃₀H₂₆FN₃O₄

: 934995-87-6
(1R,2R)-2-[4-[3-[3-cyclopropylcarbamoyl-4-oxo-1,8-naphthyridin-1-yl]phenyl]-2-fluorophenyl]cyclopropanecarboxylic acid

Guidance literature:: C₃₀H₂₆FN₃O₄; With sodium hydroxide; sodium disulfite; water; In methanol; for 2h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 - 25 ℃; for 3h;