Chemical Property of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide
Chemical Property:
- Boiling Point:761.708 °C at 760 mmHg
- Flash Point:414.467 °C
- PSA：103.54000
- Density:1.335 g/cm3
- LogP:6.02710
- Solubility.:≥25.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- XLogP3:4.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:504.21951207
- Heavy Atom Count:36
- Complexity:884
- Purity/Quality:
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99%, *data from raw suppliers
TAK-901 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C
- Recent ClinicalTrials:A Phase 1 Dose Escalation Study of TAK-901 in Subjects With Advanced Hematologic Malignancies
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Uses
A novel Aurora B kinase inhibitor with potential antineoplastic activity. It binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. A novel Aurora B kinase inhibitor with potential antineoplastic activity. It binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. It is a COVID19-related research product.
