4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile

Base Information

Chemical Name:4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile
CAS No.:392338-13-5
Molecular Formula:
Molecular Weight:
Hs Code.:
UNII:45WZM2FLYQ
Wikidata:Q27074066
Pharos Ligand ID:LNLP96NWRG9W
ChEMBL ID:CHEMBL319000
Mol file:392338-13-5.mol

Synonyms:4'-(3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy)-biphenyl-4-carbonitrile;A-331440

Suppliers and Price of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:349.215412493
Heavy Atom Count:26
Complexity:455

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN(C)C1CCN(C1)CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C#N
Isomeric SMILES:CN(C)[C@@H]1CCN(C1)CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C#N

Technology Process of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile

There total 4 articles about 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53779-90-1
dimethylaminopyrrolidine

: 392337-21-2
4'-{3-[(3R)-3-aminopyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile

: 392338-13-5
4'-{3-[(3R)-3-(dimethylamino)pyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile

Guidance literature:: With potassium iodide; potassium carbonate; In butanone;

Reference yield:

: 53779-90-1
dimethylaminopyrrolidine

: 360553-65-7
4'-(3-chloro-propoxy)-biphenyl-4-carbonitrile

: 392338-13-5
4'-{3-[(3R)-3-(dimethylamino)pyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile

Guidance literature:: With potassium iodide; potassium carbonate; In butanone;

Reference yield:

: 19812-93-2
4-Cyano-4'-hydroxybiphenyl

: 392338-13-5
4'-{3-[(3R)-3-(dimethylamino)pyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / K₂CO₃ / butan-2-one / 24 h / Heating

2: KI; K₂CO₃ / butan-2-one / 72 h / Heating

With potassium carbonate; potassium iodide; In butanone;
DOI:10.1016/S0960-894X(02)00648-0