A-867744

Base Information

Chemical Name:A-867744
CAS No.:1000279-69-5
Molecular Formula:C20H19ClN2O3S
Molecular Weight:402.89446
Hs Code.:
Mol file:1000279-69-5.mol

Synonyms:A-867744;4-[5-(4-Chlorophenyl)-2-methyl-3-propionylpyrrol-1-yl]benzenesulfonamide

Suppliers and Price of A-867744

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
A 867744
10mg
$ 460.00

TRC
A867744
5mg
$ 330.00

Tocris
A867744 ≥97%(HPLC)
10
$ 203.00

Tocris
A867744 ≥97%(HPLC)
50
$ 734.00

DC Chemicals
A-867744 >98%
250 mg
$ 1100.00

DC Chemicals
A-867744 >98%
1 g
$ 2200.00

Crysdot
A-867744 98+%
100mg
$ 727.00

Crysdot
A-867744 98+%
50mg
$ 413.00

Crysdot
A-867744 98+%
10mg
$ 88.00

ChemScene
A-867744 99.92%
50mg
$ 420.00

Total 15 raw suppliers

Chemical Property of A-867744

Chemical Property:

Boiling Point:610.0±65.0 °C(Predicted)
PKA:9.69±0.10(Predicted)
PSA：90.54000
Density:1.33±0.1 g/cm3(Predicted)
LogP:6.12730
Solubility.:Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

A 867744 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A 867744 is a positive allosteric modulator (PAM) of α7 neuronal acetylcholine receptors, which is an interaction that is used as a therapeutic approach for managing cognitive deficits in schizophrenia and Alzheimer''s disease.

Technology Process of A-867744

There total 3 articles about A-867744 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 889767-08-2
ethyl 5-(4-chlorophenyl)-2-methyl-1-(4-sulfamoylphenyl)-1H-pyrrole-3-carboxylate

: 925-90-6
ethylmagnesium bromide

: 1000279-69-5
A-867744

Guidance literature:: With N,0-dimethylhydroxylamine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1124/jpet.119.259499

Reference yield:

: 5-(4-chloro-phenyl)-1-[4-(dimethylaminomethylene-sulfamoyl)-phenyl]-2-methyl-1H-pyrrole-3-carboxylic acid N-methoxy-N-methyl-amide

: 925-90-6
ethylmagnesium bromide

: 1000279-69-5
A-867744

Guidance literature:: 5-(4-chloro-phenyl)-1-[4-(dimethylaminomethylene-sulfamoyl)-phenyl]-2-methyl-1H-pyrrole-3-carboxylic acid N-methoxy-N-methyl-amide; ethylmagnesium bromide; In tetrahydrofuran; at 20 ℃; Heating / reflux;

With water; ammonium chloride; In tetrahydrofuran;