Urea, N-(5-chloro-2-hydroxyphenyl)-N'-(2-chloro-5-(trifluoromethyl)phenyl)-

Base Information

Chemical Name:Urea, N-(5-chloro-2-hydroxyphenyl)-N'-(2-chloro-5-(trifluoromethyl)phenyl)-
CAS No.:501684-93-1
Molecular Formula:C14H9Cl2F3N2O2
Molecular Weight:365.139
Hs Code.:2924299090
European Community (EC) Number:803-753-0
NSC Number:213859
UNII:9822RX831L
DSSTox Substance ID:DTXSID50309712
Nikkaji Number:J2.869.441E
Wikidata:Q27088051
Pharos Ligand ID:CQX99FSWLALZ
ChEMBL ID:CHEMBL407217
Mol file:501684-93-1.mol

Synonyms:1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-trifluoromethylphenyl)urea;NS 1738;NS-1738;NS1738

Suppliers and Price of Urea, N-(5-chloro-2-hydroxyphenyl)-N'-(2-chloro-5-(trifluoromethyl)phenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
NS 1738
10mg
$ 403.00

Tocris
NS1738 ≥99%(HPLC)
50
$ 702.00

Tocris
NS1738 ≥99%(HPLC)
10
$ 167.00

Crysdot
NS1738 98%
10mg
$ 93.00

Crysdot
NS1738 98%
5mg
$ 70.00

Crysdot
NS1738 98%
50mg
$ 404.00

Crysdot
NS1738 98%
100mg
$ 723.00

ChemScene
NS1738 99.91%
100mg
$ 600.00

ChemScene
NS1738 99.91%
25mg
$ 210.00

ChemScene
NS1738 99.91%
50mg
$ 355.00

Total 14 raw suppliers

Chemical Property of Urea, N-(5-chloro-2-hydroxyphenyl)-N'-(2-chloro-5-(trifluoromethyl)phenyl)-

Chemical Property:

Boiling Point:344.1±42.0 °C(Predicted)
PKA:8.08±0.13(Predicted)
PSA：61.36000
Density:1.617±0.06 g/cm3(Predicted)
LogP:5.50780
Storage Temp.:Store at RT
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:4.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:363.9993174
Heavy Atom Count:23
Complexity:425

Purity/Quality:

97% ^*data from raw suppliers

NS 1738 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl
Description NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
Uses NS 1738 is a selective a7 nAchR allosteric modulator.

Technology Process of Urea, N-(5-chloro-2-hydroxyphenyl)-N'-(2-chloro-5-(trifluoromethyl)phenyl)-

There total 1 articles about Urea, N-(5-chloro-2-hydroxyphenyl)-N'-(2-chloro-5-(trifluoromethyl)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%