BS194

Base Information

• Chemical Name: BS194
• CAS No.: 1092443-55-4
• Molecular Formula: C20H27N5O3
• Molecular Weight: 385.466
• Mol file: 1092443-55-4.mol

Synonyms:BS194;CS-2655;BS-194;BS 194;(2S,3S)-3-(7-(benzylaMino)-3-isopropylpyrazolo[1,5-a]pyriMidin-5-ylaMino)butane-1,2,4-triol;(2S,3S)-3-[[3-(1-Methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]-1,2,4-butanetriol;1,2,4-Butanetriol, 3-[[3-(1-Methylethyl)-7-[(phenylMethyl)aMino]pyrazolo[1,5-a]pyriMidin-5-yl]aMino]-, (2S,3S)-

Chemical Property of BS194

Chemical Property:

• PSA: 114.94000
• LogP: 1.73680

Purity/Quality:

97% ^*data from raw suppliers

BS194 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BS194

There total 10 articles about BS194 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

tert-butyl benzyl(5-(((2S,3S)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate (1092444-51-3) → BS-194 (1092443-55-4)

Guidance literature:

With hydrogenchloride; In methanol; water; at 25 ℃; for 3h;

DOI:10.1021/jm100732t

Reference yield:

C25H35N5O5 → BS-194 (1092443-55-4)

Guidance literature:

With hydrogenchloride; In methanol; water; at 25 ℃; for 3h;

DOI:10.1021/jm100732t

Reference yield:

3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol (771510-25-9) → BS-194 (1092443-55-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trichlorophosphate / 16 h / Heating / reflux

2.1: ethanol / 3 h / Heating / reflux

3.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

4.2: 12 h / 100 °C

5.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone; tert-butyl alcohol / 14 - 18 h / 20 °C

6.1: hydrogenchloride; methanol / 6 h / 20 °C

With hydrogenchloride; methanol; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; sodium t-butanolate; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; acetone; toluene; tert-butyl alcohol;

upstream raw materials:

tert-butyl benzyl(5-(((2S,3S)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol

Isovaleronitrile

2-formyl-3-methylbutanenitrile