Chemical Property of N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
Chemical Property:
- Boiling Point:623.6±55.0 °C(Predicted)
- PKA:14.14±0.40(Predicted)
- PSA：67.35000
- Density:1.323±0.06 g/cm3(Predicted)
- LogP:5.78520
- Storage Temp.:Store at +4°C
- Solubility.:DMSO: ≥45mg/mL
- Purity/Quality:
-
99%, *data from raw suppliers
PF 3845 *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Uses
Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment. PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.[Cayman Chemical]
