Benzenesulfonamide, 2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]-

Base Information

Chemical Name:Benzenesulfonamide, 2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]-
CAS No.:1123307-53-8
Molecular Formula:C12H13Br2N3O2S
Molecular Weight:423.12352
Hs Code.:
Mol file:1123307-53-8.mol

Synonyms:2,5-Dibromo isonicotinic acid;

Suppliers and Price of Benzenesulfonamide, 2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,5-DIBROMO-N-[(3R,5S)-1-CYANO-5-METHYL-3-PYRROLIDINYL]BENZENESULFONAMIDE 95.00%
5MG
$ 495.31

Total 3 raw suppliers

Chemical Property of Benzenesulfonamide, 2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]-

Chemical Property:

PSA：81.58000
LogP:3.84338

Purity/Quality:

99% ^*data from raw suppliers

2,5-DIBROMO-N-[(3R,5S)-1-CYANO-5-METHYL-3-PYRROLIDINYL]BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzenesulfonamide, 2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]-

There total 14 articles about Benzenesulfonamide, 2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 506-68-3
bromocyane

: 1123305-82-7
1,1-dimethylethyl (2S,4R)-4-{[(2,5-dibromophenyl)sulfonyl]amino}-2-methyl-1-pyrrolidinecarboxylate

: 1123307-53-8
2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesulfonamide

Guidance literature:: 1,1-dimethylethyl (2S,4R)-4-{[(2,5-dibromophenyl)sulfonyl]amino}-2-methyl-1-pyrrolidinecarboxylate; With hydrogenchloride; for 1h;

bromocyane; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 708274-46-8,348165-63-9
1,1-dimethylethyl (2S,4R)-4-amino-2-methyl-1-pyrrolidinecarboxylate

: 1123307-53-8
2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine

2: hydrogenchloride; water / 1,4-dioxane

3: dichloromethane

With hydrogenchloride; water; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ml100212k

Reference yield:

: 135042-17-0
(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 1123307-53-8
2,5-dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: 1H-imidazole

2: lithium borohydride

3: triethylamine

4: lithium triethylborohydride

5: tetrabutyl ammonium fluoride / tetrahydrofuran

6: triethylamine

7: t-butyl ammonium azide / acetonitrile

8: 10% palladium on activated charcoal; hydrogen / methanol

9: triethylamine

10: hydrogenchloride; water / 1,4-dioxane

11: dichloromethane

With 1H-imidazole; hydrogenchloride; lithium borohydride; 10% palladium on activated charcoal; tetrabutyl ammonium fluoride; water; hydrogen; lithium triethylborohydride; triethylamine; t-butyl ammonium azide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1021/ml100212k