1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

Base Information

Chemical Name:1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
CAS No.:1216744-19-2
Molecular Formula:C₁₈H₂₁ClN₂O₄S
Molecular Weight:396.895
Hs Code.:
Mol file:1216744-19-2.mol

Synonyms:SK4112;SR6452;GSK 4112;GSK4112,SR6452;SR6452; SR-6452; SR 6452;tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate;tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate;1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate;Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester

Suppliers and Price of 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GSK 4112
10mg
$ 409.00

TRC
GSK4112
50mg
$ 370.00

Tocris
GSK4112 ≥98%(HPLC)
10
$ 169.00

Tocris
GSK4112 ≥98%(HPLC)
50
$ 711.00

DC Chemicals
GSK4112 >98%
1 g
$ 1440.00

Cayman Chemical
GSK4112 ≥98%
50mg
$ 416.00

Cayman Chemical
GSK4112 ≥98%
25mg
$ 234.00

Cayman Chemical
GSK4112 ≥98%
10mg
$ 99.00

Cayman Chemical
GSK4112 ≥98%
5mg
$ 52.00

ApexBio Technology
GSK4112
5mg
$ 50.00

Total 18 raw suppliers

Chemical Property of 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

Chemical Property:

Boiling Point:486.7±45.0 °C(Predicted)
PKA:3.87±0.50(Predicted)
PSA：103.60000
Density:1.296±0.06 g/cm3(Predicted)
LogP:5.17680
Storage Temp.:Store at +4°C
Solubility.:Chloroform (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

GSK 4112 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 41-43
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Uses GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.

Technology Process of 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

There total 2 articles about 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4521-33-9
5-nitro-2-thiophenecarboxaldehyde

: 1182917-82-3
C₁₃H₁₈ClNO₂

: 1216744-19-2
GSK 4112

Guidance literature:: With acetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm400458q

Reference yield:

: 6456-74-2
Glycine tert-butyl ester

: 104-88-1
4-chlorobenzaldehyde

: 1216744-19-2
GSK 4112

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 20 °C

2: acetic acid / dichloromethane / 20 °C

With acetic acid; In dichloromethane;
DOI:10.1021/jm400458q