2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo-

Base Information

Chemical Name:2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo-
CAS No.:1188407-45-5
Molecular Formula:C₁₉H₂₁F₂N₅O₃
Molecular Weight:405.404
Hs Code.:
Mol file:1188407-45-5.mol

2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo-

Synonyms:BMS-764459;BMS-764459 >=98% (HPLC);4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethylpyridin-3-yl]amino]-5-oxopyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-Methoxyethyl]-6-[[6-(difluoroMethoxy)-2,5-diMethyl-3-pyridinyl]aMino]-4,5-dihydro-5-oxo-

Suppliers and Price of 2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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American Custom Chemicals Corporation
4-[(1S)-1-CYCLOPROPYL-2-METHOXYETHYL]-6-[[6-(DIFLUOROMETHOXY)-2,5-DIMETHYL-3-PYRIDINYL]AMINO]-4,5-DI-2-PYRAZINE CARBONITRILE 95.00%
5MG
$ 495.58

Total 3 raw suppliers

Chemical Property of 2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo-

Chemical Property:

PSA：105.29000
LogP:2.49118

Purity/Quality:

99% ^*data from raw suppliers

4-[(1S)-1-CYCLOPROPYL-2-METHOXYETHYL]-6-[[6-(DIFLUOROMETHOXY)-2,5-DIMETHYL-3-PYRIDINYL]AMINO]-4,5-DI-2-PYRAZINE CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo-

There total 18 articles about 2-Pyrazinecarbonitrile, 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1207106-33-9
(S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-hydroxy-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile

: 120801-75-4
trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate

: 1188407-45-5
(S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile

Guidance literature:: With cesium fluoride; In acetonitrile;

Reference yield: 80.0%

: 557-21-1
zinc(II) cyanide

: 1188407-40-0
5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-2(1H)-pyrazinone

: 1188407-45-5
(S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; zinc diacetate; zinc; In 1-methyl-pyrrolidin-2-one; at 95 - 100 ℃; for 16h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op1001512

Reference yield: 72.0%

: 557-21-1
zinc(II) cyanide

: 1188407-18-2
(S)-5-Bromo-1-(cyclopropyl-2-methoxyethyl)-3-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]pyrazin-2(1H)-one

: 1188407-45-5
(S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile

Guidance literature:: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(diphenylphosphino)ferrocene; In water; N,N-dimethyl-formamide; at 120 ℃; for 3h; Inert atmosphere;