4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-

Base Information

Chemical Name:4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-
CAS No.:1197300-24-5
Molecular Formula:C18H14Cl2N2O2
Molecular Weight:361.22
Hs Code.:
Mol file:1197300-24-5.mol

Synonyms:TGR5 Receptor Agonist;heptafluoropropyl vinyl ether;Perfluoro propyl vinyl ether;Ether,heptafluoropropyl vinyl;

Suppliers and Price of 4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TGR5 Receptor Agonist
5mg
$ 493.00

DC Chemicals
CCDC(TGR5-Receptor-Agonist) >98%
1 g
$ 1900.00

DC Chemicals
CCDC(TGR5-Receptor-Agonist) >98%
250 mg
$ 950.00

Crysdot
TGR5ReceptorAgonist 98+%
50mg
$ 781.00

Crysdot
TGR5ReceptorAgonist 98+%
5mg
$ 182.00

Crysdot
TGR5ReceptorAgonist 98+%
10mg
$ 293.00

ChemScene
TGR5ReceptorAgonist 99.85%
50mg
$ 530.00

ChemScene
TGR5ReceptorAgonist 99.85%
10mg
$ 150.00

ChemScene
TGR5ReceptorAgonist 99.85%
5mg
$ 90.00

ChemScene
TGR5ReceptorAgonist 99.85%
100mg
$ 940.00

Total 29 raw suppliers

Chemical Property of 4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-

Chemical Property:

Boiling Point:541.8±50.0 °C(Predicted)
PKA:-0.52±0.50(Predicted)
PSA：46.34000
Density:1.346±0.06 g/cm3(Predicted)
LogP:5.23340
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

TGR5 Receptor Agonist ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays). It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM). TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose levels in the hepatic portal vein in dogs when administered in combination with glucose. It also inhibits the cytochrome P450 (CYP) isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively).

Technology Process of 4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-

There total 1 articles about 4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%