Glucocorticoid receptor agonist

Base Information

• Chemical Name: Glucocorticoid receptor agonist
• CAS No.: 1245526-82-2
• Molecular Formula: C20H20F4N2O2
• Molecular Weight: 396.38
• Mol file: 1245526-82-2.mol

Synonyms:CS-0520;Glucocorticoid receptor agonist;

Chemical Property of Glucocorticoid receptor agonist

Chemical Property:

• Boiling Point: 563.1±50.0 °C(Predicted)
• PKA: 10.16±0.43(Predicted)
• PSA: 69.14000
• Density: 1.373
• LogP: 4.61140

Purity/Quality:

98% ^*data from raw suppliers

Glucocorticoidreceptoragonist 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glucocorticoid receptor agonist

There total 1 articles about Glucocorticoid receptor agonist which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(R)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-ol → 4-fluoro-2-[(R)-4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)butyl]phenol (1245526-82-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/jm100751q

Refernces