BMS 665053

Base Information

Chemical Name:BMS 665053
CAS No.:1173435-64-7
Molecular Formula:C16H14Cl3F2N3O2
Molecular Weight:424.662
Hs Code.:
Mol file:1173435-64-7.mol

Synonyms:Ethyl N-Boc-D-pyroglutamate;1-Boc-D-Pyroglutamic acid ethyl ester;Ethyl Boc-D-pyroglutamate;

Suppliers and Price of BMS 665053

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
BMS-665053 ≥98% (HPLC)
25mg
$ 364.00

Sigma-Aldrich
BMS-665053 ≥98% (HPLC)
5mg
$ 83.90

American Custom Chemicals Corporation
BMS-665053 95.00%
5MG
$ 504.16

Total 5 raw suppliers

Chemical Property of BMS 665053

Chemical Property:

PSA：59.38000
LogP:4.94140
Storage Temp.:room temp

Purity/Quality:

98%,99%, ^*data from raw suppliers

BMS-665053 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of BMS 665053

There total 6 articles about BMS 665053 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2,6-dichloro-4-(difluoromethoxy)aniline

: 1173435-20-5
(S)-3,5-dichloro-1-(1-cyclopropylethyl)pyrazin-2(1H)-one

: 1173435-64-7
(S)-5-chloro-1-(1-cyclopropylethyl)-3-((2,6-dichloro-4-(difluoromethoxy)phenyl)amino)pyrazin-2-(1H)-one

Guidance literature:: With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 18h; Inert atmosphere; Reflux;
DOI:10.1021/jm900302q

Reference yield:

: 1173434-78-0
1,3-dichloro-5-(difluoromethoxy)-2-nitrobenzene

: 1173435-64-7
(S)-5-chloro-1-(1-cyclopropylethyl)-3-((2,6-dichloro-4-(difluoromethoxy)phenyl)amino)pyrazin-2-(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol

2: palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 20 °C / Reflux; Inert atmosphere

With hydrogenchloride; palladium on activated charcoal; hydrogen; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene;
DOI:10.1021/op2003198

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 1173435-64-7
(S)-5-chloro-1-(1-cyclopropylethyl)-3-((2,6-dichloro-4-(difluoromethoxy)phenyl)amino)pyrazin-2-(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; sodium nitrite / water / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 90 °C

3: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol

4: palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 20 °C / Reflux; Inert atmosphere

With hydrogenchloride; sulfuric acid; palladium on activated charcoal; hydrogen; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op2003198