1H-Pyrazole-3-methanamine, 1-(4-bromophenyl)-N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methoxy-α-methyl-, (αR)-

Base Information

Chemical Name:1H-Pyrazole-3-methanamine, 1-(4-bromophenyl)-N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methoxy-α-methyl-, (αR)-
CAS No.:1195985-43-3
Molecular Formula:C20H21BrClN3O
Molecular Weight:434.75724
Hs Code.:
Mol file:1195985-43-3.mol

Synonyms:(1R)-N-[(1R)-1-[1-(4-bromophenyl)-5-methoxypyrazol-3-yl]ethyl]-1-(3-chlorophenyl)ethanamine;1H-Pyrazole-3-MethanaMine, 1-(4-broMophenyl)-N-[(1R)-1-(3-chlorophenyl)ethyl]-5-Methoxy-α-Methyl-, (αR)-

Suppliers and Price of 1H-Pyrazole-3-methanamine, 1-(4-bromophenyl)-N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methoxy-α-methyl-, (αR)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(ALPHAR)-1-(4-BROMOPHENYL)-N-[(1R)-1-(3-CHLOROPHENYL)ETHYL]-5-METHOXY-METHYL-1H-PYRAZOLE-3-METHANAMINE 95.00%
5MG
$ 504.82

Total 2 raw suppliers

Chemical Property of 1H-Pyrazole-3-methanamine, 1-(4-bromophenyl)-N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methoxy-α-methyl-, (αR)-

Chemical Property:

PSA：39.08000
LogP:6.09950

Purity/Quality:

99% ^*data from raw suppliers

(ALPHAR)-1-(4-BROMOPHENYL)-N-[(1R)-1-(3-CHLOROPHENYL)ETHYL]-5-METHOXY-METHYL-1H-PYRAZOLE-3-METHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-methanamine, 1-(4-bromophenyl)-N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methoxy-α-methyl-, (αR)-

There total 6 articles about 1H-Pyrazole-3-methanamine, 1-(4-bromophenyl)-N-[(1R)-1-(3-chlorophenyl)ethyl]-5-methoxy-α-methyl-, (αR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1195985-60-4
1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone

: 24358-43-8,68297-62-1,147200-14-4,17061-53-9
(R)-α-(m-chlorophenyl)ethylamine

: 1195985-43-3
(1R)-1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-yl)-N-((R)-1-(3-chlorophenyl)ethyl)ethanamine

Guidance literature:: 1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone; (R)-α-(m-chlorophenyl)ethylamine; With titanium(IV) isopropylate; In tetrahydrofuran; at 35 ℃; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jm9012278

Reference yield:

: 263237-96-3
5-methoxy-1-(4-bromophenyl)-1H-pyrazole-3-carboxylic acid

: 1195985-43-3
(1R)-1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-yl)-N-((R)-1-(3-chlorophenyl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2.1: tetrahydrofuran / 0 °C

3.1: titanium(IV) isopropylate / tetrahydrofuran / 35 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

With titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: Gringnard reaction;
DOI:10.1021/jm9012278

Reference yield:

: C₁₃H₁₄BrN₃O₃

: 1195985-43-3
(1R)-1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-yl)-N-((R)-1-(3-chlorophenyl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 35 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

With titanium(IV) isopropylate; In tetrahydrofuran; 1.1: Gringnard reaction;
DOI:10.1021/jm9012278