Carbamic acid, N,N-dimethyl-, 3-[[[(2S)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]carbonyl]amino]phenyl ester

Base Information

Chemical Name:Carbamic acid, N,N-dimethyl-, 3-[[[(2S)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]carbonyl]amino]phenyl ester
CAS No.:1116570-97-8
Molecular Formula:C22H27N7O3
Molecular Weight:437.501
Hs Code.:
Mol file:1116570-97-8.mol

Synonyms:LIMKIN14;LIMK IN 14;LIMK-IN-14;LIMK inhibitor-14;LIMK inhibitor 14;MVPARBNSRQJBEM-HNNXBMFYSA-N;CarbaMic acid, N,N-diMethyl-, 3-[[[(2S)-2-Methyl-4-(5-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1-piperazinyl]carbonyl]aMino]phenyl ester

Suppliers and Price of Carbamic acid, N,N-dimethyl-, 3-[[[(2S)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]carbonyl]amino]phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-[[[(2S)-2-METHYL-4-(5-METHYL-7H-PYRROLO-[2,3-D]PYRIMIDIN-4-YL)N,N-DIMETHYL-CARBAMIC ACID 95.00%
10G
$ 1848.00

American Custom Chemicals Corporation
3-[[[(2S)-2-METHYL-4-(5-METHYL-7H-PYRROLO-[2,3-D]PYRIMIDIN-4-YL)N,N-DIMETHYL-CARBAMIC ACID 95.00%
1G
$ 1039.50

Total 4 raw suppliers

Chemical Property of Carbamic acid, N,N-dimethyl-, 3-[[[(2S)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]carbonyl]amino]phenyl ester

Chemical Property:

PSA：110.18000
LogP:3.08580

Purity/Quality:

99% ^*data from raw suppliers

3-[[[(2S)-2-METHYL-4-(5-METHYL-7H-PYRROLO-[2,3-D]PYRIMIDIN-4-YL)N,N-DIMETHYL-CARBAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, N,N-dimethyl-, 3-[[[(2S)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]carbonyl]amino]phenyl ester

There total 2 articles about Carbamic acid, N,N-dimethyl-, 3-[[[(2S)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]carbonyl]amino]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1116570-96-7
(S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1116570-97-8
(S)-3-[2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: bis(trichloromethyl) carbonate; Dimethylcarbaminsaeure-3-aminophenylester; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

(S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine; In tetrahydrofuran; for 1h;

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: 1116570-96-7
(S)-5-methyl-4-(3-methylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

: C₁₀H₁₀N₂O₃

: 1116570-97-8
(S)-3-[2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: In tetrahydrofuran; for 1h; Inert atmosphere;
DOI:10.1021/jm901226j

Reference yield:

: 1116570-97-8
(S)-3-[2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido]phenyl N,N-dimethylcarbamate

: (S)-N-[3-(isopropylcarbamoyl)phenyl]-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / 24 h / 60 °C / pH 7.2

2.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With water; triethylamine; In tetrahydrofuran;
DOI:10.1021/ml500367g