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Technology Process of 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

Base Information
  • Chemical Name:6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
  • CAS No.:356559-20-1
  • Molecular Formula:C21H21N5
  • Molecular Weight:343.42
  • Hs Code.:2934999090
  • European Community (EC) Number:636-855-7
  • ChEMBL ID:CHEMBL401570
  • DSSTox Substance ID:DTXSID801014442
  • Nikkaji Number:J3.291.007F
  • Wikidata:Q27163251
  • Mol file:356559-20-1.mol
6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

Synonyms:6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline;SB 525334;SB-525334;SB525334

Suppliers and Price of 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • SB-525334
  • 50mg
  • $ 640.00
  • Tocris
  • SB525334 ≥97%(HPLC)
  • 10
  • $ 227.00
  • Tocris
  • SB525334 ≥97%(HPLC)
  • 50
  • $ 952.00
  • TCI Chemical
  • SB-525334
  • 50MG
  • $ 702.00
  • TCI Chemical
  • SB-525334
  • 10MG
  • $ 195.00
  • Sigma-Aldrich
  • TGF-β RI Kinase Inhibitor VIII
  • 2mg
  • $ 211.00
  • Sigma-Aldrich
  • SB-525334 ≥98% (HPLC)
  • 5mg
  • $ 200.00
  • Sigma-Aldrich
  • SB-525334 ≥98% (HPLC)
  • 25mg
  • $ 792.00
  • Matrix Scientific
  • 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline 95+%
  • 250mg
  • $ 1255.00
  • DC Chemicals
  • SB525334 99%
  • 250 mg
  • $ 700.00
Total 40 raw suppliers
Chemical Property of 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:159 °C 
  • Boiling Point:515.314°C at 760 mmHg 
  • PKA:10.24±0.10(Predicted) 
  • Flash Point:265.453°C 
  • PSA：67.35000 
  • Density:1.191 
  • LogP:4.68780 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: ≥20mg/mL 
  • XLogP3:3.7
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:3
  • Exact Mass:343.17969569
  • Heavy Atom Count:26
  • Complexity:476
Purity/Quality:

99%, *data from raw suppliers

SB-525334 *data from reagent suppliers

Safty Information:
  • Pictogram(s): Xn 
  • Hazard Codes:Xn 
  • Statements: 22-36/37/38 
  • Safety Statements: 26 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
  • Description SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression. It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis. SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.
  • Uses SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 = 14.3 nM. SB-525334 was used to study TGFβ1-mediated human trophoblast differentiation.7
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