L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-

Base Information

Chemical Name:L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-
CAS No.:210354-22-6
Molecular Formula:C8H17N3O2S
Molecular Weight:219.30759
Hs Code.:
UNII:0ZZF1V8G63
Nikkaji Number:J1.265.182A
Wikidata:Q27251084
Pharos Ligand ID:78HF5UQDS384
Metabolomics Workbench ID:153264
ChEMBL ID:CHEMBL114551
Mol file:210354-22-6.mol

Synonyms:GW 274150;GW274150

Suppliers and Price of L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
GW274150 >98%
1 g
$ 3200.00

DC Chemicals
GW274150 >98%
250 mg
$ 1600.00

CSNpharm
GW274150
1mg
$ 140.00

CSNpharm
GW274150
10mg
$ 420.00

Crysdot
GW274150 98+%
10mg
$ 650.00

Crysdot
GW274150 98+%
5mg
$ 455.00

ChemScene
GW274150
10mg
$ 450.00

ChemScene
GW274150
5mg
$ 300.00

ChemScene
GW274150
50mg
$ 1000.00

ChemScene
GW274150
25mg
$ 700.00

Total 13 raw suppliers

Chemical Property of L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-

Chemical Property:

Boiling Point:392.3±52.0 °C(Predicted)
PKA:2.22±0.10(Predicted)
PSA：121.21000
Density:1.30±0.1 g/cm3(Predicted)
LogP:1.19830
XLogP3:-3.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:219.10414797
Heavy Atom Count:14
Complexity:209

Purity/Quality:

99%, ^*data from raw suppliers

GW274150 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=NCCSCCC(C(=O)O)N)N
Isomeric SMILES:CC(=NCCSCC[C@@H](C(=O)O)N)N
Recent ClinicalTrials:Study With GW274150 In Patients With Mild Asthma
Recent EU Clinical Trials:A Multicentre, Two-Part, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy,Tolerability and Pharmacokinetics of the iNOS Inhibitor GW274150 Administered up to 120mg Daily for 12 Weeks in the Prophylactic Treatment of Migraine.

Technology Process of L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-

There total 5 articles about L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57512-01-3
(S)-2-Amino-4-(2-benzyloxycarbonylamino-ethylsulfanyl)-butyric acid

: 210354-22-6
GW274150

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / dioxane

2: 85 percent / HCO₂H / Pd / methanol / Heating

3: ethanol

4: HCl / dioxane

With hydrogenchloride; sodium hydroxide; formic acid; palladium; In 1,4-dioxane; methanol; ethanol; 1: Acylation / 2: Hydrogenolysis / 3: Condensation / 4: Hydrolysis; Decarboxylation;
DOI:10.1016/S0960-894X(00)00055-X

Reference yield:

: 84792-75-6
S-(2-Benzyloxycarbonylaminoethyl)-N-tert-butoxy-carbonyl-L-homocysteine

: 210354-22-6
GW274150

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / HCO₂H / Pd / methanol / Heating

2: ethanol

3: HCl / dioxane

With hydrogenchloride; formic acid; palladium; In 1,4-dioxane; methanol; ethanol; 1: Hydrogenolysis / 2: Condensation / 3: Hydrolysis; Decarboxylation;
DOI:10.1016/S0960-894X(00)00055-X

Reference yield:

: 210354-30-6
4-(2-benzyloxycarbonylamino-ethylsulfanyl)-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester

: 210354-22-6
GW274150

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / HCO₂NH₄ / Pd(OH)2/C / ethanol / Heating

2: ethanol

3: HCl / dioxane

With hydrogenchloride; ammonium formate; palladium dihydroxide; In 1,4-dioxane; ethanol; 1: Hydrogenolysis / 2: Condensation / 3: Hydrolysis; Decarboxylation;
DOI:10.1016/S0960-894X(00)00055-X