4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE
• CAS No.: 37663-44-8
• Molecular Formula: C12H16ClNO
• Molecular Weight: 225.718
• Hs Code.: 2934999090
• Mol file: 37663-44-8.mol

Synonyms:3H-Spiro[Isobenzofuran-1,4''-Piperidine] Hcl;1,3-Dihydrospiro[isobenzofuran-1,4'-piperidine] hydrochloride;3H-Spiro[isobenzofuran-1,4'-piperidine] hydrochloride;Spiro[phthalan-1,4'-piperidine] hydrochloride;

Chemical Property of 4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 21.26000
• LogP: 2.92630
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Spiro[isobenzofuran-1(3H),4''-piperidine]Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Spiro[isobenzofuran-1(3H),4'-piperidine] is a (spiro)(hetero)cyclic amides as modulator of 11-β hydroxysteroid dehydrogenase type 1. Spiro[isobenzofuran-1(3H),4''-piperidine] is a (spiro)(hetero)cyclic amides as modulator of 11-β hydroxysteroid dehydrogenase type 1.

Technology Process of 4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE

There total 1 articles about 4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1'-benzyl-3H-spiro[isobenzofuran-1,4'-piperidine]; hydrochloride (54596-09-7) → spiro[isobenzofuran-1(3H),4’-piperidin]-3-one hydrochloride (37663-44-8)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In methanol; at 20 ℃; for 21h; under 760.051 Torr;

Reference yield: 78.0%

4-diphenylsulfonyl chloride (1623-93-4) + spiro[isobenzofuran-1(3H),4’-piperidin]-3-one hydrochloride (37663-44-8) → C24H23NO3S

Guidance literature:

With pyridine; at 80 ℃;

Reference yield: 63.0%

2,3-dichloropyridine-4-carbaldehyde (884495-41-4) + spiro[isobenzofuran-1(3H),4’-piperidin]-3-one hydrochloride (37663-44-8) → 2,3-dichloro-4-(3H-spiro[2-benzofuran-1,4'-piperidine]-1'-yl)methylpyridine (1152617-83-8)

Guidance literature:

2,3-dichloropyridine-4-carbaldehyde; spiro[isobenzofuran-1(3H),4’-piperidin]-3-one hydrochloride; With sodium triacetoxyborohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane;

upstream raw materials:

1'-benzyl-3H-spiro[isobenzofuran-1,4'-piperidine]; hydrochloride

Downstream raw materials:

1-(4-fluoro-phenyl)-4-(3H-spiro[isobenzofuran-1,4'-piperidin]-1'-yl)-butan-1-one

2,3-dichloro-4-(3H-spiro[2-benzofuran-1,4'-piperidine]-1'-yl)methylpyridine

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