2-Oxetanemethanamine

Base Information

• Chemical Name: 2-Oxetanemethanamine
• CAS No.: 882402-12-2
• Molecular Formula: C4H9NO
• Molecular Weight: 87.12
• Hs Code.: 2932999099
• European Community (EC) Number: 800-793-0
• DSSTox Substance ID: DTXSID90604738
• Mol file: 882402-12-2.mol

Synonyms:2-OXETANEMETHANAMINE;oxetan-2-ylmethanamine;882402-12-2;C-OXETAN-2-YL-METHYLAMINE;2-AMINOMETHYLOXETANE;(R)-C-Oxetan-2-yl-methylamine;(S)-C-Oxetan-2-yl-methylamine;MFCD17214171;Oxetane-2-methanamine;Oxetan-2-ylmethylamine;MFCD30183309;MFCD31727897;aminomethyl oxetane;2-Oxetanylmethanamine;2-(Aminomethyl)oxetane;(oxetan-2-yl)methanamine;1-oxetan-2-ylmethanamine;C-Oxetan-2-ylmethylamine;(R)-Oxetane-2-methanamine;1-(Oxetan-2-yl)methanamine;DTXSID90604738;QDEFNAHLCTUWAH-UHFFFAOYSA-N;BCP30690;AKOS006347122;PB12865;SB35255;SB35261;SY035857;SY250609;SY262593;DB-003255;AM20020052;CS-0048767;EN300-781099;J-510195

Chemical Property of 2-Oxetanemethanamine

Chemical Property:

• Boiling Point: 130.9±13.0 °C(Predicted)
• PKA: 9.47±0.29(Predicted)
• PSA: 35.25000
• Density: 1.004±0.06 g/cm3(Predicted)
• LogP: 0.43430
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 87.068413911
• Heavy Atom Count: 6
• Complexity: 46.8

Purity/Quality:

97% ^*data from raw suppliers

oxetan-2-ylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC1CN

Technology Process of 2-Oxetanemethanamine

There total 1 articles about 2-Oxetanemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-(2-oxetanylmethyl)-1H-isoindole-1,3(2H)-dione (882402-11-1) → 1-(oxetan-2-yl)methanamine (882402-12-2)

Guidance literature:

2-(2-oxetanylmethyl)-1H-isoindole-1,3(2H)-dione; With ethanol; hydrazine; for 0.5h; Heating / reflux;

With ethanol; Raney Ni (W-2); for 1.5h; Heating / reflux;

Reference yield: 71.0%

6-chloro-2-[1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-one (438450-40-9) + 1-(oxetan-2-yl)methanamine (882402-12-2) → N-(4-chloro-2-methyl-6-[([oxetan-2-ylmethyl]amino)carbonyl]phenyl)-1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (882401-65-2)

Guidance literature:

In tetrahydrofuran; for 0.5h; Heating / reflux;

Reference yield:

1-(oxetan-2-yl)methanamine (882402-12-2) + 1-[1-(4-cyanophenyl)ethyl]-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid (1571135-31-3) → C26H23F3N4O3 (1571134-18-3)

Guidance literature:

With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; acetonitrile; at 0 ℃;

upstream raw materials:

2-(2-oxetanylmethyl)-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

N-(4-chloro-2-methyl-6-[([oxetan-2-ylmethyl]amino)carbonyl]phenyl)-1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

C₂₆H₂₃F₃N₄O₃

N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-(oxetan-2-ylmethyl)pyrido[3,4-d]pyrimidine-2,8-diamine