2-(Piperidin-4-yl)pyridine dihydrochloride

Base Information

• Chemical Name: 2-(Piperidin-4-yl)pyridine dihydrochloride
• CAS No.: 143924-45-2
• Molecular Formula: C10H16Cl2N2
• Molecular Weight: 235.16
• Hs Code.: 2933990090
• European Community (EC) Number: 853-092-7
• DSSTox Substance ID: DTXSID40582436
• Mol file: 143924-45-2.mol

Synonyms:2-(Piperidin-4-yl)pyridine dihydrochloride;143924-45-2;2-(1 lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride;2-piperidin-4-ylpyridine;dihydrochloride;2-(Piperidin-4-yl)pyridine 2HCl;2-(Piperidin-4-yl)pyridinedihydrochloride;SCHEMBL4008149;DTXSID40582436;MFCD14583122;AKOS015991356;EE-0216;SB43623;CS-0145564;C77434;EN300-1222682;A884874;J-506555;2-(Piperidin-4-yl)pyridine--hydrogen chloride (1/2);Pyridine, 2-(4-piperidinyl)-, hydrochloride (1:2);2-(Piperidin-4-yl)pyridine dihydrochloride, AldrichCPR;F2167-2633

Chemical Property of 2-(Piperidin-4-yl)pyridine dihydrochloride

Chemical Property:

• PSA: 24.92000
• LogP: 3.48140
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 234.0690539
• Heavy Atom Count: 14
• Complexity: 130

Purity/Quality:

99%, ^*data from raw suppliers

2-(Piperidin-4-yl)pyridinedihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C2=CC=CC=N2.Cl.Cl

Technology Process of 2-(Piperidin-4-yl)pyridine dihydrochloride

There total 6 articles about 2-(Piperidin-4-yl)pyridine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-carboxylic acid tert-butyl ester (206446-49-3) → 1',2',3',4',5',6'-hexahydro-2'H-[2,4'-bipyridine] dihydrochloride (143924-45-2,216688-64-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at -78 - 20 ℃;

DOI:10.1021/jm060662k

Reference yield: 99.0%

→ 1',2',3',4',5',6'-hexahydro-2'H-[2,4'-bipyridine] dihydrochloride (143924-45-2,216688-64-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 1',2',3',4',5',6'-hexahydro-2'H-[2,4'-bipyridine] dihydrochloride (143924-45-2,216688-64-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 68 percent / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.1: 64 percent / Pd(PPh₃)4 / tetrahydrofuran / 1.5 h / 60 °C

3.1: 99 percent / H₂ / Pd/C / 1.5 h / 20 °C / 3102.89 Torr

4.1: 99 percent / HCl gas / ethyl acetate / -78 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; hydrogen; diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate; 2.1: Negishi cross-coupling;

DOI:10.1021/jm060662k

upstream raw materials:

4-(2-pyridyl)pyridine

3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one

4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

4-(2-pyridinyl)piperidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 143924-45-2 2-(1 LAMDA{2}-PIPERIDIN-4-YL)PYRIDIN-4-YL DIHYDROCHLORIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send