5-Bromo-3-methoxypicolinaldehyde

Base Information

• Chemical Name: 5-Bromo-3-methoxypicolinaldehyde
• CAS No.: 1087659-24-2
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.03
• Hs Code.: 2933399090
• Mol file: 1087659-24-2.mol

Synonyms:5-bromo-3-methoxypyridine-2-carbaldehyde;

Chemical Property of 5-Bromo-3-methoxypicolinaldehyde

Chemical Property:

• Boiling Point: 281.3±40.0 °C(Predicted)
• PKA: 0.83±0.10(Predicted)
• PSA: 39.19000
• Density: 1.606±0.06 g/cm3(Predicted)
• LogP: 1.66520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-3-methoxypicolinaldehyde ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-3-methoxypicolinaldehyde is a versatile building block used in the synthesis of various pharmaceuticals.

Technology Process of 5-Bromo-3-methoxypicolinaldehyde

There total 3 articles about 5-Bromo-3-methoxypicolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(5-bromo-3-methoxypyridin-2-yl)methanol (1087659-32-2) → 5-bromo-3-methoxypicolinaldehyde (1087659-24-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 17 - 25 ℃; for 1h; Inert atmosphere;

Reference yield:

methyl 5-bromo-3-methoxvpicolinate (1142192-55-9) → 5-bromo-3-methoxypicolinaldehyde (1087659-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; sodium tetrahydroborate / 4 h / 0 - 23 °C

2: Dess-Martin periodane / dichloromethane / 3 h / 0 - 23 °C

With sodium tetrahydroborate; ethanol; Dess-Martin periodane; In dichloromethane;

Reference yield:

5-bromo-3-methoxy-pyridine-2-carboxylic acid (1142191-66-9) → 5-bromo-3-methoxypicolinaldehyde (1087659-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / 0.5 h / -10 - 25 °C / Inert atmosphere

1.2: 0.5 h / 17 - 25 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 17 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; Dess-Martin periodane; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane;

upstream raw materials:

methyl 5-bromo-3-methoxvpicolinate

(5-bromo-3-methoxypyridin-2-yl)methanol

5-bromo-3-methoxy-pyridine-2-carboxylic acid

Downstream raw materials:

(5-bromo-3-methoxypyridin-2-yl)methanol

Refernces

• 1、 -. "HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES". . . Retrieved 2015/11/09.