Octimibate

Base Information

• Chemical Name: Octimibate
• CAS No.: 89838-96-0
• Molecular Formula: C29H30 N2 O3
• Molecular Weight: 454.569
• Hs Code.: 2933290090
• Mol file: 89838-96-0.mol

Synonyms:BMY 22389;NAT 04-152; Octimibate

Chemical Property of Octimibate

Chemical Property:

• Vapor Pressure: 2.22E-17mmHg at 25°C
• Boiling Point: 642.4°C at 760 mmHg
• Flash Point: 342.3°C
• PSA: 64.35000
• Density: 1.13g/cm³
• LogP: 7.01030

Purity/Quality:

OCTIMIBATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Octimibate

There total 3 articles about Octimibate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 8-(1,4,5-triphenylimidazol-2-yloxy)-caprylate (89838-82-4) → 8-(1,4,5-triphenylimidazol-2-yloxy)-caprylic acid (89838-96-0)

Guidance literature:

With sodium hydroxide; In methanol; water;

Reference yield:

8-hydroxycaprylic acid (764-89-6) + 2-chloro-1,4,5-triphenyl-1H-imidazole (76463-85-9) → 8-(1,4,5-triphenylimidazol-2-yloxy)-caprylic acid (89838-96-0)

Guidance literature:

In N-methyl-acetamide;

Reference yield:

methyl 8-bromooctanoate (26825-92-3) + 1,4,5-triphenyl-1,3-dihydro-2H-imidazol-2-one (26497-68-7) → 8-(1,4,5-triphenylimidazol-2-yloxy)-caprylic acid (89838-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide

2: sodium hydroxide / methanol; water

With sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

8-hydroxycaprylic acid

2-chloro-1,4,5-triphenyl-1H-imidazole

methyl 8-(1,4,5-triphenylimidazol-2-yloxy)-caprylate

methyl 8-bromooctanoate

Downstream raw materials:

8-(1,4,5-Triphenylimidazol-2-yl-oxy)octanamide

Refernces

• 1、 -. "Triphenylimidazolyloxyalkanoic acids and their derivatives and a process for the treatment of thromboembolic, inflammatory and/or atheriosclerotic diseases". . . Retrieved 2015/03/06.