2-N-boc-butane-1,2-diamine-hcl

Base Information

• Chemical Name: 2-N-boc-butane-1,2-diamine-hcl
• CAS No.: 138374-00-2
• Molecular Formula: C9H20N2O2.HCL
• Molecular Weight: 224.7282
• Hs Code.: 2924199090
• Mol file: 138374-00-2.mol

Synonyms:2-N-Boc-butane-1,2-diamine-HCl;2-N-Boc-Butane-1,2-diaMine hydrochloride

Chemical Property of 2-N-boc-butane-1,2-diamine-hcl

Chemical Property:

• PSA: 64.35000
• LogP: 3.14160

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(1-aminobutan-2-yl)carbamatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-N-boc-butane-1,2-diamine-hcl

There total 3 articles about 2-N-boc-butane-1,2-diamine-hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-azido-2-(N-tert-butoxycarbonylamino)butane (138373-90-7) → 2-(N-tert-butoxycarbonyl)-1,2-diaminobutane hydrochloride (138374-00-2)

Guidance literature:

With chloroform; hydrogen; palladium on activated charcoal; In methanol; for 3h; under 1551.4 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)91013-0

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-(N-tert-butoxycarbonyl)-1,2-diaminobutane hydrochloride (138374-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / 1N aq. NaOH / CH₂Cl₂ / Ambient temperature

2: 82 percent / PPh₃, HN₃, diethyl azodicarboxylate / benzene; CH₂Cl₂ / Ambient temperature

3: 80 percent / H₂, CHCl₃ / 10percent Pd/C / methanol / 3 h / 1551.4 Torr / Ambient temperature

With sodium hydroxide; chloroform; tris-(2-chloro-ethyl)-amine; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In methanol; dichloromethane; benzene;

DOI:10.1016/S0040-4020(01)91013-0

Reference yield:

(1-(hydroxymethyl)propyl)carbamic acid tert-butyl ester (193086-15-6) → 2-(N-tert-butoxycarbonyl)-1,2-diaminobutane hydrochloride (138374-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / PPh₃, HN₃, diethyl azodicarboxylate / benzene; CH₂Cl₂ / Ambient temperature

2: 80 percent / H₂, CHCl₃ / 10percent Pd/C / methanol / 3 h / 1551.4 Torr / Ambient temperature

With chloroform; tris-(2-chloro-ethyl)-amine; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In methanol; dichloromethane; benzene;

DOI:10.1016/S0040-4020(01)91013-0

upstream raw materials:

1-azido-2-(N-tert-butoxycarbonylamino)butane

di-tert-butyl dicarbonate

(1-(hydroxymethyl)propyl)carbamic acid tert-butyl ester

Refernces