Tert-butyl 3-(iodomethyl)azetidine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 3-(iodomethyl)azetidine-1-carboxylate
• CAS No.: 253176-94-2
• Molecular Formula: C9H16INO2
• Molecular Weight: 297.13
• Hs Code.: 2933998090
• European Community (EC) Number: 812-172-1
• DSSTox Substance ID: DTXSID50693143
• Wikidata: Q72503460
• Mol file: 253176-94-2.mol

Synonyms:253176-94-2;TERT-BUTYL 3-(IODOMETHYL)AZETIDINE-1-CARBOXYLATE;1-Boc-3-(iodomethyl)azetidine;N-Boc-3-(iodomethyl)azetidine;MFCD09951816;N-boc-3-iodomethylazetidine;tert-butyl3-(iodomethyl)azetidine-1-carboxylate;SCHEMBL3001141;DTXSID50693143;CJVGFEARJOREHI-UHFFFAOYSA-N;AKOS015837066;CS-W014547;PB31449;AM808148;AS-33519;SY029741;BB 0262977;FT-0683045;EN300-6729032;tert-butyl-3-(iodomethyl)azetidin-1-carboxylate;A817782;J-524496;tert-butyl 3-(iodanylmethyl)azetidine-1-carboxylate;3-(iodomethyl)-1-azetidinecarboxylic acid tert-butyl ester;3-Iodomethyl-azetidine-1-carboxylic acid tert-butyl ester;1-AZETIDINECARBOXYLIC ACID, 3-(IODOMETHYL)-, 1,1-DIMETHYLETHYL ESTER

Chemical Property of Tert-butyl 3-(iodomethyl)azetidine-1-carboxylate

Chemical Property:

• Boiling Point: 300.9±15.0 °C(Predicted)
• PKA: -2.17±0.40(Predicted)
• Density: 1.571±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 297.02258
• Heavy Atom Count: 13
• Complexity: 194

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(iodomethyl)azetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CC(C1)CI

Technology Process of Tert-butyl 3-(iodomethyl)azetidine-1-carboxylate

There total 3 articles about Tert-butyl 3-(iodomethyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-({[(4-methylphenyl)sulfonyl]oxy}methyl)azetidine-1-carboxylate (892408-42-3) → 3-iodomethylazetidine-1-carboxylic acid tert-butyl ester (253176-94-2)

Guidance literature:

With lithium iodide; In acetone; at 35 ℃; for 16h;

Reference yield:

3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester (142253-56-3) → 3-iodomethylazetidine-1-carboxylic acid tert-butyl ester (253176-94-2)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane;

DOI:10.1016/S0960-894X(02)00689-3

Reference yield:

3-bromomethyl-azetidine-1-carboxylic acid tert-butyl ester (253176-93-1) → 3-iodomethylazetidine-1-carboxylic acid tert-butyl ester (253176-94-2)

Guidance literature:

With sodium iodide; In acetonitrile; at 65 ℃; for 2.5h;

upstream raw materials:

3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester

3-bromomethyl-azetidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-({[(4-methylphenyl)sulfonyl]oxy}methyl)azetidine-1-carboxylate

Downstream raw materials:

(2S,3R)-3-(1-tert-Butoxycarbonyl-azetidin-3-ylmethyl)-4-oxo-azetidine-2-carboxylic acid benzyl ester