2-(2-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-(2-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE
• CAS No.: 50481-48-6
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Hs Code.: 2921499090
• Mol file: 50481-48-6.mol

Synonyms:2-(2-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE

Chemical Property of 2-(2-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 245.6±15.0 °C(Predicted)
• PKA: 8.82±0.10(Predicted)
• PSA: 26.02000
• Density: 1.092±0.06 g/cm3(Predicted)
• LogP: 3.23410

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Chlorophenyl)propan-2-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE

There total 7 articles about 2-(2-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-chloro-α,α-dimethylbenzenemethanamide (103753-46-4) → 2-chloro-α,α-dimethylbenzenemethanamine (50481-48-6)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In water; acetonitrile; at 20 ℃; for 24h;

DOI:10.1021/jo000418f

Reference yield: 36.0%

[1-(2-chlorophenyl)-1-methyl-ethyl]-carbamic acid ethyl ester (736055-28-0) → 2-chloro-α,α-dimethylbenzenemethanamine (50481-48-6)

Guidance literature:

With sodium hydroxide; In water; ethylene glycol; at 110 ℃; for 15h;

Reference yield:

2-(2-chlorophenyl)-2-methylpropanenitrile (69849-08-7) → 2-chloro-α,α-dimethylbenzenemethanamine (50481-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / aq. K₂CO₃; conc. H₂O₂ / ethanol / 14 h / 20 °C

2: 71 percent / bis(trifluoroacetoxy)iodobenzene / acetonitrile; H₂O / 24 h / 20 °C

With dihydrogen peroxide; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; In ethanol; water; acetonitrile;

DOI:10.1021/jo000418f

upstream raw materials:

1-Chloro-2-(1-isocyanato-1-methyl-ethyl)-benzene

2-chloro-α,α-dimethylbenzenemethanamide

2-(2-chlorophenyl)-2-methylpropanenitrile

1-(2-chlorophenyl)ethanone