5-Carboxy-2-Aminoadamantane

Base Information

• Chemical Name: 5-Carboxy-2-Aminoadamantane
• CAS No.: 1057343-95-9
• Molecular Formula: C11H17NO2
• Molecular Weight: 195.26
• Hs Code.: 2922499990
• Mol file: 1057343-95-9.mol

Synonyms:4-Aminotricyclo[3.3.1.13,7]decane-1-carboxylic acid;

Chemical Property of 5-Carboxy-2-Aminoadamantane

Chemical Property:

• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 161.7 °C
• PSA: 63.32000
• Density: 1.267 g/cm³
• LogP: 1.92490

Purity/Quality:

99%min ^*data from raw suppliers

4-Aminoadamantane-1-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Carboxy-2-Aminoadamantane

There total 20 articles about 5-Carboxy-2-Aminoadamantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-oxoadamantan-1-carboxylic acid → 4-aminoadamantan-1-carboxylic acid (1057343-95-9,898265-47-9)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.25h; Reflux;

Reference yield: 86.0%

4-oxoadamantane-1-carboxylic acid → (E)-4-amino-adamantane-1-carboxylic acid (1057343-95-9,898265-47-9)

Guidance literature:

With ammonia; hydrogen; 5%-palladium/activated carbon; In methanol; at 23 ℃; for 16 - 24h;

Reference yield: 86.0%

4-oxoadamantane-1-carboxylic acid (56674-87-4) → 4-amino-adamantane-1-carboxylic acid (1057343-95-9,898265-47-9)

Guidance literature:

With 5%-palladium/activated carbon; ammonia; hydrogen; In methanol; for 18h;

DOI:10.1039/c5md00043b

upstream raw materials:

4-oxoadamantane-1-carboxylic acid

chemantane

adamantanone

5-hydroxyadamantan-2-one

Downstream raw materials:

E-4-amino-adamantane-1-carboxylic acid methyl ester

(E)-methyl 4-aminoadamantane-1-carboxylate

Z-4-adamantamine-1-carboxylic acid methyl ester

Refernces

• 1、 Mandi?, Leo,Mlinari?-Majerski, Kata,Griesbeck, Axel G.,Basari?, Nikola. "Photodecarboxylation of Adamantane Amino Acids Activated by Phthalimide". supporting information. p. 4404 - 4414. Retrieved 2016/09/14.
• 2、 -. "A COMPOUND FOR INHIBITING 11B-HYDROXY STEROID DEHYDROGENASE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME". Paragraph 0228-0229. . Retrieved 2014/08/06.