(2S)-5-Oxo-1,2-piperidinedicarboxylic acid 1-benzyl ester

Base Information

Chemical Name:(2S)-5-Oxo-1,2-piperidinedicarboxylic acid 1-benzyl ester
CAS No.:117836-14-3
Molecular Formula:C14H15NO5
Molecular Weight:277.27
Hs Code.:
DSSTox Substance ID:DTXSID101206775
Mol file:117836-14-3.mol

Synonyms:117836-14-3;(2S)-5-Oxo-1,2-piperidinedicarboxylic acid 1-benzyl ester;(2S)-5-oxo-1-phenylmethoxycarbonylpiperidine-2-carboxylic acid;(2S)-1-[(benzyloxy)carbonyl]-5-oxopiperidine-2-carboxylic acid;1-benzyloxycarbonyl-5-keto-(S)-pipecolic acid;SCHEMBL9173220;IBZDRDHRFDYPTQ-LBPRGKRZSA-N;DTXSID101206775;DB-309791;1-(Phenylmethyl) (2S)-5-oxo-1,2-piperidinedicarboxylate;(2S)-1-[(benzyloxy)carbonyl]-5-oxopiperidine-2-carboxylicacid

Suppliers and Price of (2S)-5-Oxo-1,2-piperidinedicarboxylic acid 1-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (2S)-5-Oxo-1,2-piperidinedicarboxylic acid 1-benzyl ester

Chemical Property:

PSA：0.00000
Density:1.355
LogP:0.00000
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:277.09502258
Heavy Atom Count:20
Complexity:389

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)CN(C1C(=O)O)C(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CC(=O)CN([C@@H]1C(=O)O)C(=O)OCC2=CC=CC=C2

Technology Process of (2S)-5-Oxo-1,2-piperidinedicarboxylic acid 1-benzyl ester

There total 2 articles about (2S)-5-Oxo-1,2-piperidinedicarboxylic acid 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 147489-30-3
(2S)-5-oxopiperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 117836-14-3
N-benzyloxycarbonyl-5-oxo-(S)-pipecolic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2006.07.035

Reference yield:

: 146467-21-2,789448-80-2
(±)-5-oxopiperidine-2-carboxylic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 117836-14-3
5-oxo-piperidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: With hydrogenchloride; sodium hydroxide; In water; pH=10.5;

Reference yield:

: 117836-14-3
5-oxo-piperidine-1,2-dicarboxylic acid 1-benzyl ester

: C₁₈H₂₅NO₅

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2: sodium tetrahydroborate / methanol

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;