6-Fluoroimidazo[1,2-a]pyridine-2-methanol

Base Information

• Chemical Name: 6-Fluoroimidazo[1,2-a]pyridine-2-methanol
• CAS No.: 1038827-63-2
• Molecular Formula: C8H7FN2O
• Molecular Weight: 166.15
• Hs Code.: 2933998090
• Mol file: 1038827-63-2.mol

Synonyms:(6-Fluoro-imidazo[1,2-a]pyridin-2-yl)-methanol;(6-fiuoroimidazo[1,2-a]pyridin-2-yl)methanol;6-fluoroimidazo[1,2-a]pyridine-2-methanol;

Chemical Property of 6-Fluoroimidazo[1,2-a]pyridine-2-methanol

Chemical Property:

• PKA: 13.31±0.10(Predicted)
• PSA: 37.53000
• Density: 1.38
• LogP: 0.96570

Purity/Quality:

97% ^*data from raw suppliers

(6-Fluoroimidazo[1,2-a]pyridin-2-yl)-methanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoroimidazo[1,2-a]pyridine-2-methanol

There total 3 articles about 6-Fluoroimidazo[1,2-a]pyridine-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-fluoroimidazo[1,2-a]pyridine-2-carboxylic acid (367500-94-5) → (6-fluoroimidazo[1,2-a]pyridin-2-yl)methanol (1038827-63-2)

Guidance literature:

6-fluoroimidazo[1,2-a]pyridine-2-carboxylic acid; With borane-THF; In tetrahydrofuran; for 3h; Heating / reflux;

With methanol; In tetrahydrofuran; for 18h; Heating / reflux;

Reference yield:

6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (367500-93-4) → (6-fluoroimidazo[1,2-a]pyridin-2-yl)methanol (1038827-63-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/acsmedchemlett.5b00008

Reference yield:

2-amino-5-fluoropyridine (21717-96-4) → (6-fluoroimidazo[1,2-a]pyridin-2-yl)methanol (1038827-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; ethanol;

DOI:10.1021/acsmedchemlett.5b00008

upstream raw materials:

6-fluoroimidazo[1,2-a]pyridine-2-carboxylic acid

2-amino-5-fluoropyridine

6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Downstream raw materials:

6-fluoroimidazo[1,2-a]pyridine-2-carbaldehyde

2-(chloromethyl)-6-fluoroimidazo[1,2-a]pyridine

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