5,6-Dihydro-5-oxoindolo[1,2-a]quinazoline-7-acetic acid

Base Information

Chemical Name:5,6-Dihydro-5-oxoindolo[1,2-a]quinazoline-7-acetic acid
CAS No.:391670-48-7
Molecular Formula:C17H12N2O3
Molecular Weight:292.2928
Hs Code.:
Mol file:391670-48-7.mol

Synonyms:Casein Kinase II Inhibitor IX, IQA;2-(5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid;5,6-Dihydro-5-oxoindolo[1,2-a]quinazoline-7-acetic acid;2-(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid;Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem

Suppliers and Price of 5,6-Dihydro-5-oxoindolo[1,2-a]quinazoline-7-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem
5mg
$ 227.55

Total 4 raw suppliers

Chemical Property of 5,6-Dihydro-5-oxoindolo[1,2-a]quinazoline-7-acetic acid

Chemical Property:

PSA：74.83000
Density:1.46
LogP:2.97340
Storage Temp.:+2C to +8C

Purity/Quality:

97% ^*data from raw suppliers

Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5,6-Dihydro-5-oxoindolo[1,2-a]quinazoline-7-acetic acid

There total 4 articles about 5,6-Dihydro-5-oxoindolo[1,2-a]quinazoline-7-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 391670-41-0
(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid methyl ester

: 391670-48-7
2-(5-oxo-6H-indolo[1,2-a]quinazolin-7-yl)acetic acid

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/jm030827e

Reference yield:

: 78880-65-6
5-cyano-10-oxo-10,11-dihydro-5H-dibenz[b,f]-azepine

: 391670-48-7
2-(5-oxo-6H-indolo[1,2-a]quinazolin-7-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / t-BuOK / 1,2-dichloro-ethane / 2 h / 20 °C

2: K₂CO₃ / dimethylformamide / 0 - 20 °C

3: 67 percent / NaOMe / 65 °C

4: 95 percent / aq. NaOH / dimethylsulfoxide / 20 °C

With sodium hydroxide; potassium tert-butylate; sodium methylate; potassium carbonate; In dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030827e

Reference yield:

: 391671-05-9
11-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-10-carbonitrile

: 391670-48-7
2-(5-oxo-6H-indolo[1,2-a]quinazolin-7-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 0 - 20 °C

2: 67 percent / NaOMe / 65 °C

3: 95 percent / aq. NaOH / dimethylsulfoxide / 20 °C

With sodium hydroxide; sodium methylate; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm030827e