6,7-Dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline

Base Information

Chemical Name:6,7-Dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline
CAS No.:927691-21-2
Molecular Formula:C₂₂H₂₁N₅O₃
Molecular Weight:403.44
Hs Code.:
DSSTox Substance ID:DTXSID10470891
Mol file:927691-21-2.mol

Synonyms:927691-21-2;6,7-dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline;PQ 10;A844337;6,7-DIMETHOXY-4-[3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE;PQ10;SCHEMBL4404999;DTXSID10470891;AKOS037643512;NCGC00402348-02;AS-16700;A 844337;A-844337;6,7-dimethoxy-4-[3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline

Suppliers and Price of 6,7-Dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
PQ-10 ≥98% (HPLC)
25mg
$ 385.00

Sigma-Aldrich
PQ-10 ≥98% (HPLC)
5mg
$ 97.80

Cayman Chemical
PQ-10 ≥98%
10mg
$ 166.00

Cayman Chemical
PQ-10 ≥98%
5mg
$ 93.00

Cayman Chemical
PQ-10 ≥98%
1mg
$ 38.00

Cayman Chemical
PQ-10 ≥98%
25mg
$ 368.00

Biosynth Carbosynth
(R)-6,7-Dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
5 mg
$ 350.00

Biosynth Carbosynth
(R)-6,7-Dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
25 mg
$ 1000.00

Biosynth Carbosynth
(R)-6,7-Dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
10 mg
$ 550.00

Biosynth Carbosynth
(R)-6,7-Dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
100 mg
$ 2500.00

Total 15 raw suppliers

Chemical Property of 6,7-Dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline

Chemical Property:

PSA：82.49000
Density:1.333
LogP:3.31290
Storage Temp.:2-8°C
Solubility.:DMSO: soluble10mg/mL, clear
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:403.16443955
Heavy Atom Count:30
Complexity:569

Purity/Quality:

99%, ^*data from raw suppliers

PQ-10 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC=N2)N3CCC(C3)OC4=NC5=CC=CC=C5N=C4)OC
Description PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM). It has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. Subcutaneous injection of PQ-10 (32 mg/kg) leads to increases in striatal cGMP and phosphorylation of cAMP response element binding protein (CREB) in murine striatum, known markers of in vivo PDE10 inhibition. PQ-10 at a dose of 0.3 mg/kg, p.o., reduces scopolamine- and MK-801-induced memory deficits in rats. PQ-10 also inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively.

Technology Process of 6,7-Dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline

There total 8 articles about 6,7-Dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (R)-2-(pyrrolidine-3-yloxy)quinoxaline

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 927691-21-2
PQ10

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; at 80 ℃; for 16h;
DOI:10.1021/jm060653b

Reference yield: 58.0%

: 1421124-85-7
(S)-2-(pyrrolidine-3-yloxy)quinoxaline

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 927691-21-2
(S)-6,7-dimethoxy-4-(3-(quinoxaline-2-yloxy)pyrrolidine-1-yl)quinazoline

Guidance literature:: With potassium carbonate; In 1,4-dioxane; water; at 80 ℃;
DOI:10.1002/cmdc.201300522

Reference yield: 15.0%

: C₁₇H₂₁N₃O₃

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 927691-21-2
PQ10

Guidance literature:: C₁₇H₂₁N₃O₃; With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 20h;

6,7-dimethoxy-4-chloroquinazoline; With potassium carbonate; In toluene; at 80 ℃; for 16h;