4-BROMO-6-FLUORO (1H)INDAZOLE

Base Information

• Chemical Name: 4-BROMO-6-FLUORO (1H)INDAZOLE
• CAS No.: 885520-35-4
• Molecular Formula: C7H4BrFN2
• Molecular Weight: 215.025
• Hs Code.: 2933998090
• Mol file: 885520-35-4.mol

Synonyms:1H-Indazole,4-bromo-6-fluoro-;

Chemical Property of 4-BROMO-6-FLUORO (1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 0.000303mmHg at 25°C
• Refractive Index: 1.693
• Boiling Point: 331.3 °C at 760 mmHg
• PKA: 12.00±0.40(Predicted)
• Flash Point: 154.1 °C
• PSA: 28.68000
• Density: 1.861 g/cm³
• LogP: 2.46450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-6-fluoro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-6-FLUORO (1H)INDAZOLE

There total 1 articles about 4-BROMO-6-FLUORO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

→ 4-bromo-6-fluoro-1H-indazole (885520-35-4)

Guidance literature:

Reference yield: 42.5%

4-bromo-6-fluoro-1H-indazole (885520-35-4) + 3-benzyl-3-azabicyclo[3.3.1]nonan-9-one (81879-64-3) → 3-benzyl-9-(6-fluoro-1H-indazol-4-yl)-3-azabicyclo[3.3.1]nonan-9-ol

Guidance literature:

4-bromo-6-fluoro-1H-indazole; 3-benzyl-3-azabicyclo[3.3.1]nonan-9-one; With sodium hydride; In tetrahydrofuran; at -78 - 0 ℃; for 0.583333h; Inert atmosphere;

With tert.-butyl lithium; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

4-bromo-6-fluoro-1H-indazole (885520-35-4) + 4-benzyloxy-3-fluorophenylboronic acid (133057-83-7) → 4-bromo-6-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazole (1056263-61-6)

Guidance literature:

With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 96h; Molecular sieve;

Downstream raw materials:

4-bromo-6-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazole

1-(6-fluoro-1-methyl-1H-indazol-4-yl)ethanone

6-fluoro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol

6-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazol-4-ol

Refernces

• 1、 -. "TREATMENT OF CANCERS HAVING K-RAS MUTATIONS". Paragraph 0281. . Retrieved 2013/05/08.