2-Chloropyridine-4-sulfonyl chloride

Base Information

• Chemical Name: 2-Chloropyridine-4-sulfonyl chloride
• CAS No.: 1000933-25-4
• Molecular Formula: C5H3Cl2NO2S
• Molecular Weight: 212.05
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40655770
• Wikidata: Q72458585
• Mol file: 1000933-25-4.mol

Synonyms:2-CHLOROPYRIDINE-4-SULFONYL CHLORIDE;1000933-25-4;2-Chloro-4-Pyridinesulfonyl chloride;2-Chloro-4-pyridinesulfonylchloride;SCHEMBL724036;DTXSID40655770;YQKSHKJJXUAFAN-UHFFFAOYSA-N;GS3006;AKOS005264785;GS-5519;2-CHLOROPYRIDINE-4-SULFONYLCHLORIDE;CS-0034011;H10628

Chemical Property of 2-Chloropyridine-4-sulfonyl chloride

Chemical Property:

• PSA: 55.41000
• Density: 1.615
• LogP: 2.74330
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 210.9261549
• Heavy Atom Count: 11
• Complexity: 223

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-4-pyridinesulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1S(=O)(=O)Cl)Cl

Technology Process of 2-Chloropyridine-4-sulfonyl chloride

There total 3 articles about 2-Chloropyridine-4-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloropyridine-4-sulfonyl chloride (1000933-25-4)

Guidance literature:

4-Amino-2-chloropyridine; With hydrogenchloride; sulfur dioxide; acetic acid; trifluoroacetic acid; sodium nitrite; In water; at 0 ℃; for 1h;

With sulfur dioxide; copper(l) chloride; copper dichloride; at 0 ℃; for 1.5h;

Reference yield:

lithium 2-chloropyridine-4-sulfinate → 2-chloropyridine-4-sulfonyl chloride (1000933-25-4)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

2-chloro-4-bromopyridine (73583-37-6) → 2-chloropyridine-4-sulfonyl chloride (1000933-25-4)

Guidance literature:

2-chloro-4-bromopyridine; With n-butyllithium; dibutylmagnesium; In tetrahydrofuran; at -10 ℃; Inert atmosphere;

With sulfuryl dichloride; In tetrahydrofuran; toluene; at -10 - 10 ℃;

DOI:10.1055/s-0030-1259953

upstream raw materials:

2-chloro-4-bromopyridine

4-Amino-2-chloropyridine

Refernces

• 1、 -. "NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS". . . Retrieved 2019/01/21.
• 2、 -. "PYRIDYL-AMINE FUSED AZADECALIN MODULATORS". Page/Page column 86-87. . Retrieved 2012/03/26.