5-isothiocyanatoquinoline

Base Information

• Chemical Name: 5-isothiocyanatoquinoline
• CAS No.: 1001183-84-1
• Molecular Formula: C₁₀H₆N₂S
• Molecular Weight: 186.237
• Mol file: 1001183-84-1.mol

Synonyms:5-isothiocyanato quinoline;

Chemical Property of 5-isothiocyanatoquinoline

Chemical Property:

• PSA: 57.34000
• LogP: 2.96910

Purity/Quality:

99% ^*data from raw suppliers

5-Isothiocyanatoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-isothiocyanatoquinoline

There total 3 articles about 5-isothiocyanatoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Aminoquinoline (611-34-7,146614-41-7) → 5-isothiocyanatoquinoline (1001183-84-1)

Guidance literature:

With 1,1'-Thiocarbonyldiimidazole; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

5-Aminoquinoline (611-34-7,146614-41-7) + thiophosgene (463-71-8) → 5-isothiocyanatoquinoline (1001183-84-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2007.04.099

Reference yield:

→ 5-isothiocyanatoquinoline (1001183-84-1)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1.5h;

upstream raw materials:

5-Aminoquinoline

thiophosgene

Downstream raw materials:

C₂₅H₂₆ClN₇O

Refernces

• 1、 -. "PIPERAZINES AS P2X7 ANTAGONISTS". Page/Page column 60. . Retrieved 2008/06/13.