N-[(1R)-1-(Hydroxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]carbamic acid benzyl ester

Base Information

Chemical Name:N-[(1R)-1-(Hydroxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]carbamic acid benzyl ester
CAS No.:219835-31-1
Molecular Formula:C18H20N2O4
Molecular Weight:328.368
Hs Code.:2924299090
Mol file:219835-31-1.mol

Synonyms:(R)-N-Benzyl-2-N-(Benzyloxycarbonyl)Amino-3-Hydroxypropionamide

Suppliers and Price of N-[(1R)-1-(Hydroxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]carbamic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-Benzyl(1-(benzylamino)-3-hydroxy-1-oxopropan-2-yl)carbamate 95+%
1g
$ 772.00

ChemScene
(R)-benzyl1-(benzylamino)-3-hydroxy-1-oxopropan-2-ylcarbamate
100g
$ 605.00

Chemenu
(R)-Benzyl(1-(benzylamino)-3-hydroxy-1-oxopropan-2-yl)carbamate 95%
1g
$ 729.00

American Custom Chemicals Corporation
(R)-BENZYL(1-(BENZYLAMINO)-3-HYDROXY-1-OXOPROPAN-2-YL)CARBAMATE 95.00%
100G
$ 1012.20

American Custom Chemicals Corporation
(R)-BENZYL(1-(BENZYLAMINO)-3-HYDROXY-1-OXOPROPAN-2-YL)CARBAMATE 95.00%
5MG
$ 501.44

Alichem
(R)-Benzyl(1-(benzylamino)-3-hydroxy-1-oxopropan-2-yl)carbamate
1g
$ 690.80

Total 18 raw suppliers

Chemical Property of N-[(1R)-1-(Hydroxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]carbamic acid benzyl ester

Chemical Property:

Melting Point:147-149℃
PSA：94.64000
Density:1.238
LogP:2.63480
Storage Temp.:2-8°C

Purity/Quality:

98% Min ^*data from raw suppliers

(R)-Benzyl(1-(benzylamino)-3-hydroxy-1-oxopropan-2-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[(1R)-1-(Hydroxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]carbamic acid benzyl ester

There total 4 articles about N-[(1R)-1-(Hydroxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 6081-61-4
N-(benzyloxycarbonyl)-D-serine

: 100-46-9
benzylamine

: 219835-31-1
(R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide

Guidance literature:: N-(benzyloxycarbonyl)-D-serine; With 4-methyl-morpholine; isobutyl chloroformate; In ethyl acetate; at -10 ℃;

benzylamine; In ethyl acetate; at 20 ℃; Cooling;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 219835-31-1
(R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water / 24.75 h / 0 - 20 °C / Inert atmosphere

1.2: pH 1

2.1: 4-methyl-morpholine / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

3.1: tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydrogencarbonate; In tetrahydrofuran; water;
DOI:10.1021/jm2004305

Reference yield:

: 6081-61-4
N-(benzyloxycarbonyl)-D-serine

: 219835-31-1
(R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-hydroxypropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 4-methylmorpholine / 1.) THF, -78 deg C, 2 min, 2.) THF, -78 deg C, 2 min

2: tetrahydrofuran / 1 h / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran;
DOI:10.1016/S0957-4166(98)00403-0