3-Bromoacetyl-2-thiophenesulfonamide

Base Information

• Chemical Name: 3-Bromoacetyl-2-thiophenesulfonamide
• CAS No.: 154127-28-3
• Molecular Formula: C6H6BrNO3S2
• Molecular Weight: 284.15
• Hs Code.: 2935009090
• Mol file: 154127-28-3.mol

Synonyms:2-thiophenesulfonamide, 3-(2-bromoacetyl)-; 3-(Bromoacetyl)thiophene-2-sulfonamide

Chemical Property of 3-Bromoacetyl-2-thiophenesulfonamide

Chemical Property:

• Vapor Pressure: 1.96E-08mmHg at 25°C
• Refractive Index: 1.632
• Boiling Point: 454.1 °C at 760 mmHg
• PKA: 9.40±0.60(Predicted)
• Flash Point: 228.4 °C
• PSA: 113.85000
• Density: 1.862 g/cm³
• LogP: 2.75420
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Bromoacetyl)thiophene-2-sulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromoacetyl-2-thiophenesulfonamide

There total 1 articles about 3-Bromoacetyl-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-Acetylthiophene-2-sulfonamide (138890-88-7) → 3-(2-bromoacetyl)thiophene-2-sulfonamide (154127-28-3)

Guidance literature:

3-Acetylthiophene-2-sulfonamide; With toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 0.5h;

With N-Bromosuccinimide; In acetonitrile; for 2h; Heating / reflux;

Reference yield: 76.0%

3-(2-bromoacetyl)thiophene-2-sulfonamide (154127-28-3) → 3,4-dihydro-4(S)-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide (174139-70-9)

Guidance literature:

3-(2-bromoacetyl)thiophene-2-sulfonamide; With (+)-β-chlorodiisopinocampheylborane; In tetrahydrofuran; hexane; at -40 - -20 ℃; for 4h;

With sodium hydroxide; In tetrahydrofuran; hexane; water; at 0 - 20 ℃; for 10h;

Reference yield: 76.0%

3-(2-bromoacetyl)thiophene-2-sulfonamide (154127-28-3) → 3,4-dihydro-4(R)-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide (1029324-93-3)

Guidance literature:

3-(2-bromoacetyl)thiophene-2-sulfonamide; With (-)-β-chlorodiisopinocampheylborane; In tetrahydrofuran; at -40 - -20 ℃; for 4h;

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 10h;

upstream raw materials:

3-Acetylthiophene-2-sulfonamide

Downstream raw materials:

3,4-dihydro-4(S)-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide

3,4-dihydro-4(R)-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide

3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide