REF DUPL: Fmoc-Asp(OtBu)-(Dmb)Gly-OH

Base Information

• Chemical Name: REF DUPL: Fmoc-Asp(OtBu)-(Dmb)Gly-OH
• CAS No.: 900152-72-9
• Molecular Formula: C₃₄H₃₈N₂O₉
• Molecular Weight: 618.684
• Mol file: 900152-72-9.mol

Synonyms:(S)-2-(2-(((9H-fluoren-9-yl)methyl9H-fluoren-9-yl)methoxy)carbonylamino)-4-tert-butoxy-N-(2,4-dimethoxybenzyl)-4-oxobutanamido)acetic acid;Fmoc-Asp(OtBu)-(Dmb)Gly-OH;REF DUPL: Fmoc-Asp(OtBu)-(Dmb)Gly-OH;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alpha-aspartyl-N-[(2,4-dimethoxyphenyl)methyl]glycine 1-(1,1-dimethylethyl) ester

Chemical Property of REF DUPL: Fmoc-Asp(OtBu)-(Dmb)Gly-OH

Chemical Property:

• PSA: 154.69000
• Density: 1.259
• LogP: 5.23660

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-L-Asp(tBu)-DmbGly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of REF DUPL: Fmoc-Asp(OtBu)-(Dmb)Gly-OH

There total 1 articles about REF DUPL: Fmoc-Asp(OtBu)-(Dmb)Gly-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-l-Asp(OtBu)-OSu + (2,4-dimethoxy-benzylamino)-acetic acid (20839-79-6) → N-alpha-Fmoc-N-beta-O-t-butyl-L-aspartyl-N-α-(2,4-dimethoxybenzyl)glycine (900152-72-9)

Guidance literature:

(2,4-dimethoxy-benzylamino)-acetic acid; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane;

Fmoc-l-Asp(OtBu)-OSu; With N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.tetlet.2006.04.074

Reference yield:

N-alpha-Fmoc-N-beta-O-t-butyl-L-aspartyl-N-α-(2,4-dimethoxybenzyl)glycine (900152-72-9) + C66H83N8O14Pol + C27H22N2O5 + Fmoc-Glu(OtBu)-OH (71989-18-9) + N-(9-fluorenylmethoxycarbonyl)-D-alanine (35661-38-2,35661-39-3,79990-15-1,136132-75-7) + Fmoc-Orn(Boc)-OH (109425-55-0,118476-89-4) + Nα-(9-fluorenylmethoxycarbonyl)-D-serine-tert-butyl ether (71989-33-8,128107-47-1) → C112H154N18O28

Guidance literature:

C₆₆H₈₃N₈O₁₄Pol; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; In dichloromethane; for 1h; Inert atmosphere;

N-alpha-Fmoc-N-beta-O-t-butyl-L-aspartyl-N-α-(2,4-dimethoxybenzyl)glycine; C₂₇H₂₂N₂O₅; Fmoc-Glu(OtBu)-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine; Fmoc-Orn(Boc)-OH; Nα-(9-fluorenylmethoxycarbonyl)-D-serine-tert-butyl ether; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;

In dichloromethane; N,N-dimethyl-formamide; for 1h; Inert atmosphere;

DOI:10.1039/c3ob42238k

Reference yield:

N-alpha-Fmoc-N-beta-O-t-butyl-L-aspartyl-N-α-(2,4-dimethoxybenzyl)glycine (900152-72-9) + C66H83N8O14Pol + C27H22N2O5 + Fmoc-Glu(OtBu)-OH (71989-18-9) + N-(9-fluorenylmethoxycarbonyl)-D-alanine (35661-38-2,35661-39-3,79990-15-1,136132-75-7) + Fmoc-Orn(Boc)-OH (109425-55-0,118476-89-4) + Nα-(9-fluorenylmethoxycarbonyl)-D-serine-tert-butyl ether (71989-33-8,128107-47-1) → C112H154N18O28

Guidance literature:

C₆₆H₈₃N₈O₁₄Pol; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; In dichloromethane; for 1h; Inert atmosphere;

N-alpha-Fmoc-N-beta-O-t-butyl-L-aspartyl-N-α-(2,4-dimethoxybenzyl)glycine; C₂₇H₂₂N₂O₅; Fmoc-Glu(OtBu)-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine; Fmoc-Orn(Boc)-OH; Nα-(9-fluorenylmethoxycarbonyl)-D-serine-tert-butyl ether; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;

In dichloromethane; N,N-dimethyl-formamide; for 1h; Inert atmosphere;

DOI:10.1039/c3ob42238k

upstream raw materials:

(2,4-dimethoxy-benzylamino)-acetic acid

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