3-BROMO-6-METHYL-7-AZAINDOLE

Base Information

• Chemical Name: 3-BROMO-6-METHYL-7-AZAINDOLE
• CAS No.: 1000340-28-2
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.05858
• Hs Code.: 2933990090
• Mol file: 1000340-28-2.mol

Synonyms:3-BROMO-6-METHYL-7-AZAINDOLE;3-broMo-6-Methyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-broMo-6-Methyl-

Chemical Property of 3-BROMO-6-METHYL-7-AZAINDOLE

Chemical Property:

• PSA: 28.68000
• LogP: 2.63380
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-6-METHYL-7-AZAINDOLE

There total 5 articles about 3-BROMO-6-METHYL-7-AZAINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.93%

6-methyl-1H-pyrrolo<2,3-b>pyridine (824-51-1) → 3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine (1000340-28-2)

Guidance literature:

With hydrogenchloride; N-Bromosuccinimide; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

1H-Pyrrolo[2,3-b]pyridine-7-oxide (55052-24-9) → 3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine (1000340-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere

1.2: 2 h / 20 °C

2.1: methanol; sodium hydroxide / 4 h / 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,2-dimethoxyethane / 2 h / 120 °C / Microwave irradiation

4.1: N-Bromosuccinimide; sulfuric acid / tetrahydrofuran / 2 h / 20 °C

With methanol; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (849068-50-4) → 3-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine (1000340-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; sodium hydroxide / 4 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,2-dimethoxyethane / 2 h / 120 °C / Microwave irradiation

3: N-Bromosuccinimide; sulfuric acid / tetrahydrofuran / 2 h / 20 °C

With methanol; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane;

upstream raw materials:

1H-Pyrrolo[2,3-b]pyridine-7-oxide

ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

6-chloro-7-azaindole

6-methyl-1H-pyrrolo<2,3-b>pyridine

Downstream raw materials:

tert-butyl 2-(1-(2-(acetamidomethyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

tert-butyl 2-(1-(2-(ethanethioamidomethyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

?tert-butyl 2-(1-(2-((3,5-dimethyl-4H-1,2,4-triazol-4-yl)methyl)-4-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

Refernces

• 1、 -. "NEW CRTH2 ANTAGONISTS". . . Retrieved 2013/03/26.