N-Acetoxy Cyclosporin A Acetate

Base Information

• Chemical Name: N-Acetoxy Cyclosporin A Acetate
• CAS No.: 138957-23-0
• Molecular Formula: C31H59N3O7
• Molecular Weight: 585.81606
• Mol file: 138957-23-0.mol

Synonyms:N-Acetoxy Cyclosporin A Acetate;6-[(3R,4R,6E)-3,8-Bis(acetyloxy)-6,7-didehydro-N,4-diMethyl-L-2-aMinooctanoic acid]cyclosporin A

Chemical Property of N-Acetoxy Cyclosporin A Acetate

Chemical Property:

• PSA: 134.60000
• LogP: 5.47870
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

AcetoxyCyclosporinAAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Cyclosporin A

Technology Process of N-Acetoxy Cyclosporin A Acetate

There total 2 articles about N-Acetoxy Cyclosporin A Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

tetraethylammonium acetate tetrahydrate (67533-12-4) + acetyl-η-bromocylosporin A (138957-22-9) → η-acetoxyacetylcyclosporin A (138957-23-0)

Guidance literature:

With sodium iodide; In butanone; a.) 105 deg C, 3 h, b) r.t., 2 days;

DOI:10.1021/jo00035a027

Reference yield:

cyclosproin A acetate (83602-41-9) → η-acetoxyacetylcyclosporin A (138957-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 2.5 h / Heating

2: 72 percent / NaI / butan-2-one / a.) 105 deg C, 3 h, b) r.t., 2 days

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium iodide; In tetrachloromethane; butanone;

DOI:10.1021/jo00035a027

Reference yield: 94.0%

η-acetoxyacetylcyclosporin A (138957-23-0) → AM1 (89270-28-0)

Guidance literature:

With methanol; sodium; for 2.5h; Ambient temperature;

DOI:10.1021/jo00035a027

upstream raw materials:

tetraethylammonium acetate tetrahydrate

acetyl-η-bromocylosporin A

cyclosproin A acetate

Downstream raw materials:

AM1

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