6-Aminopyridine-3-sulfonyl chloride

Base Information

• Chemical Name: 6-Aminopyridine-3-sulfonyl chloride
• CAS No.: 289483-92-7
• Molecular Formula: C5H5ClN2O2S
• Molecular Weight: 192.626
• DSSTox Substance ID: DTXSID10477724
• Wikidata: Q82310601
• Mol file: 289483-92-7.mol

Synonyms:6-Aminopyridine-3-sulfonyl chloride;289483-92-7;3-Pyridinesulfonyl chloride, 6-amino-;6-Amino-3-pyridinesulfonyl Chloride;SCHEMBL17998;DTXSID10477724;MFNXODBGVQIFPM-UHFFFAOYSA-N;GS2992;MFCD18254623;AKOS006335124;EN300-276070;A937082

Chemical Property of 6-Aminopyridine-3-sulfonyl chloride

Chemical Property:

• PSA: 82.16000
• LogP: 1.60220
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 191.9760263
• Heavy Atom Count: 11
• Complexity: 223

Purity/Quality:

99% ^*data from raw suppliers

6-Amino-3-pyridinesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1S(=O)(=O)Cl)N
• Uses: 6-Amino-3-pyridinesulfonyl Chloride was used in discovery and structure activity relationship study of potent and selective covalent inhibitors of transglutaminase 2 for Huntington’s Disease.

Technology Process of 6-Aminopyridine-3-sulfonyl chloride

There total 2 articles about 6-Aminopyridine-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-aminopyridine (504-29-0) → 6-Amino-3-pyridinesulfonyl Chloride (289483-92-7)

Guidance literature:

With chlorosulfonic acid; at 0 ℃; for 2h; Reflux;

DOI:10.1021/jm201310y

Reference yield:

2-aminopyridine (504-29-0) → 6-Amino-3-pyridinesulfonyl Chloride (289483-92-7) + 2-amino-pyridine-3-sulfonyl chloride (70661-77-7)

Guidance literature:

With chlorosulfonic acid; thionyl chloride; at 0 - 150 ℃; Inert atmosphere; sealed tube;

Reference yield: 9.0%

6-Amino-3-pyridinesulfonyl Chloride (289483-92-7) + 6-methyl-2-(piperazine-1-yl)-N-(p-tolyl)pyrimidin-4-amine → C21H25N7O2S

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;

upstream raw materials:

2-aminopyridine

Downstream raw materials:

C₂₃H₂₃FN₄O₅S₂

2-(4-(4-((6-amino-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

2-(4-((2R)-4-((6-amino-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

2-(4-((2S)-4-((6-amino-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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